INT100612

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.30
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) intracellular (Hsp90aa1) protein complex (Hsp90aa1)
cytoplasm (Hsp90aa1) cytosol (Hsp90aa1) protein folding (Hsp90aa1)
Anatomy Link Frequency
neurons 1
Hsp90aa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 25 98.72 Very High Very High Very High
Morphine 4 98.48 Very High Very High Very High
agonist 1 89.44 High High
ischemia 8 84.96 Quite High
Peripheral nerve injury 10 84.28 Quite High
Opioid 2 80.40 Quite High
Nucleus accumbens 2 79.16 Quite High
anesthesia 9 68.84 Quite High
Peripheral nervous system 1 52.80 Quite High
Sciatic nerve 8 17.52 Low Low
Disease Link Frequency Relevance Heat
Shock 26 100.00 Very High Very High Very High
Hypoxia 4 99.98 Very High Very High Very High
Injury 38 99.50 Very High Very High Very High
Sprains And Strains 4 99.16 Very High Very High Very High
Stress 202 98.82 Very High Very High Very High
Ganglion Cysts 25 98.72 Very High Very High Very High
Disorders Of Creatine Metabolism 6 92.56 High High
Wound Healing 4 86.68 High High
Cv Unclassified Under Development 8 84.96 Quite High
Nervous System Injury 14 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction ability of the gastric mucosal HSP60 (Bonferroni correction, p = 0.013) and HSP90 (Bonferroni correction, p = 0.002) by the 12 h WI-stress was significantly higher in the females than in the males (Fig. 1g).
Positive_regulation (induction) of HSP90 associated with stress
1) Confidence 0.64 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.82 Pain Relevance 0
These observations suggested that the gender difference observed in the development of the stress-induced gastric mucosal injury in rats might be partly explained by the differences in the gastric mucosal levels of HSP90, HSP70, and HSP60 induced by estrogen.
Positive_regulation (induced) of HSP90 associated with stress and injury
2) Confidence 0.46 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.75 Pain Relevance 0
We also found a significant upregulation of the Hsp90beta protein in both strains 8h after morphine injection, this increase being significantly higher in Lewis rats.
Positive_regulation (upregulation) of Hsp90 associated with sprains and strains and morphine
3) Confidence 0.45 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562399 Disease Relevance 0.35 Pain Relevance 0.59
Another recent report demonstrated that hypoxia-induced HSP90?
Positive_regulation (induced) of HSP90 associated with hypoxia
4) Confidence 0.43 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.75 Pain Relevance 0
Moreover, heat shock strongly induced renal HSP72 and HSP32/HO-1, and to a lesser extent HSP90, expression.
Positive_regulation (induced) of HSP90 associated with shock
5) Confidence 0.42 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.01 Pain Relevance 0.18
Taking these reports and our present data together, HSP90 is known to play an important role in the reduction of stress-induced gastric mucosal injury in females via an estrogen-HSP90 relationship with HSF1 activation.


Positive_regulation (activation) of HSP90 associated with stress and injury
6) Confidence 0.37 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.74 Pain Relevance 0
Injured adult DRG neurons do not die after axonal injury [15] as a result of the upregulation of cell survival factors such as the small heat shock protein HSP27 [16].
Positive_regulation (upregulation) of heat shock protein HSP27 in neurons associated with dorsal root ganglion, shock and injury
7) Confidence 0.05 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139981 Disease Relevance 0.87 Pain Relevance 0.24

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