INT100658

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.39
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
hippocampus 4
spinal 2
paw 2
neurons 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 55 100.00 Very High Very High Very High
Morphine 26 100.00 Very High Very High Very High
tolerance 9 100.00 Very High Very High Very High
Antinociceptive 5 100.00 Very High Very High Very High
Nucleus accumbens 2 100.00 Very High Very High Very High
cocaine 14 99.98 Very High Very High Very High
nMDA receptor antagonist 5 99.78 Very High Very High Very High
Hippocampus 12 99.68 Very High Very High Very High
Dorsal horn neuron 12 99.08 Very High Very High Very High
Thermal hyperalgesia 26 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 38 100.00 Very High Very High Very High
Hyperalgesia 50 98.38 Very High Very High Very High
Injury 19 98.28 Very High Very High Very High
Stress Incontinence 3 87.36 High High
Nociception 28 74.92 Quite High
INFLAMMATION 18 74.44 Quite High
Neuropathic Pain 36 70.16 Quite High
Death 5 63.76 Quite High
Inflammatory Pain 14 63.08 Quite High
Ganglion Cysts 11 57.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Negative_regulation (presented) of Positive_regulation (increase) of NR2B in hippocampus associated with nucleus accumbens, hippocampus and cocaine
1) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.35
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Negative_regulation (presented) of Positive_regulation (increase) of NR2B in hippocampus associated with nucleus accumbens, hippocampus and cocaine
2) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.36
This suggests that the interaction of endogenous ephrin with EphB receptors on dorsal horn neurons was prevented by the soluble receptor, hence preventing the phosphorylation of NR2B induced by carrageenan.


Negative_regulation (preventing) of Positive_regulation (induced) of NR2B in neurons associated with dorsal horn neuron
3) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.46 Pain Relevance 0.43
We also showed that blockage of endogenous EphB receptor activation by intrathecal injection with EphB1-Fc chimeras, which we had previously shown to inhibit the behavioral and thermal hyperalgesia induced by carrageenan injection in the hind paw (Battaglia et al., 2003), also inhibited the phosphorylation of NR2B induced by this injection.
Negative_regulation (inhibited) of Positive_regulation (induced) of NR2B in paw associated with thermal hyperalgesia and intrathecal
4) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.31 Pain Relevance 0.47
Moreover, compared with the control group, both the increase in pNR2B and the cross-organ reflex sensitization were attenuated in the si-RNA of NR2B rats.
Negative_regulation (attenuated) of Positive_regulation (increase) of pNR2B
5) Confidence 0.35 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.27 Pain Relevance 0.61
MK-801, a noncompetitive NMDA receptor antagonist, not only suppressed morphine antinociceptive tolerance and the increase in NR2B, but also reduced the spinal JNK activation induced by chronic morphine treatment.
Negative_regulation (suppressed) of Positive_regulation (increase) of NR2B in spinal associated with nmda receptor antagonist, tolerance, antinociceptive and morphine
6) Confidence 0.35 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.66
Our results indicate that increased NR2B in the penumbra after 24 h of focal cerebral ischemia may be comprised of combinations of NR2B subunit, along with the NR1 subunit (Monyer et al., 1992).
Negative_regulation (comprised) of Positive_regulation (increased) of NR2B associated with brain hemorrhage and ischemia
7) Confidence 0.31 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.36 Pain Relevance 0.29

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