INT100886

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 5.63
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
Anatomy Link Frequency
colon 2
internal 1
oviducts 1
oocytes 1
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
cINOD 41 99.84 Very High Very High Very High
COX2 4 98.78 Very High Very High Very High
Inflammation 24 91.48 High High
Pain 2 89.44 High High
Paracetamol 2 68.88 Quite High
Inflammatory response 2 52.72 Quite High
endometriosis 84 5.00 Very Low Very Low Very Low
cytokine 40 5.00 Very Low Very Low Very Low
Dismenorea 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 243 100.00 Very High Very High Very High
Colon Cancer 88 99.72 Very High Very High Very High
INFLAMMATION 37 99.12 Very High Very High Very High
Cancer 144 95.12 Very High Very High Very High
Stomach Cancer 4 93.40 High High
Coma 2 92.80 High High
Pain 2 89.44 High High
Adhesions 14 88.08 High High
Apoptosis 83 86.44 High High
Eclampsia 40 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that NSAIDs and resveratrol cause increases in the expression of gamma-glutamylcysteine synthetase mRNA and identify these agents as being capable of stimulating glutathione metabolism.
Gene_expression (expression) of gamma-glutamylcysteine synthetase mRNA associated with cinod
1) Confidence 0.76 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.10
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Gene_expression (expression) of gamma-glutamylcysteine synthetase
2) Confidence 0.76 Published 2002 Journal Free Radic. Biol. Med. Section Title Doc Link 11909699 Disease Relevance 0.10 Pain Relevance 0.19
Consistent with this idea, over-expression of Nrf2 increased GCLC reporter gene expression and over-expression of KIAA0132 inhibited GCLC reporter gene activity as well as inhibited indomethacin-induced increases in the expression of GCLC.
Gene_expression (expression) of GCLC
3) Confidence 0.76 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.07
Consistent with this idea, over-expression of Nrf2 increased GCLC reporter gene expression and over-expression of KIAA0132 inhibited GCLC reporter gene activity as well as inhibited indomethacin-induced increases in the expression of GCLC.
Gene_expression (expression) of GCLC
4) Confidence 0.76 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.08
Indomethacin-induced increases in the expression of gamma-glutamylcysteine synthetase mRNA were preceded by increases in steady state levels of intracellular pro-oxidants and glutathione disulfide accumulation.
Gene_expression (expression) of gamma-glutamylcysteine synthetase mRNA
5) Confidence 0.76 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.08 Pain Relevance 0.17
Indirect immunofluorescence using intact cells demonstrated that indomethacin induced the nuclear translocation of Nrf2, a transcription factor believed to regulate GCLC expression.
Gene_expression (expression) of GCLC
6) Confidence 0.76 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.06 Pain Relevance 0.12
Both simple scales identified distinct GCS ranges, although some overlap occurred (p < 0.001).
Gene_expression (identified) of GCS
7) Confidence 0.65 Published 2004 Journal Anaesthesia Section Abstract Doc Link 14687096 Disease Relevance 0.26 Pain Relevance 0.09
Exposure of HepG2 cells to nonsteroidal anti-inflammatory drugs (i.e., indomethacin and ibuprofen; NSAIDs) as well as resveratrol, caused increased expression of the mRNAs coding for the catalytic (Gclc) and modifier (Gclm) subunits of the glutathione synthetic enzyme, gamma-glutamylcysteine synthetase.
Gene_expression (expression) of gamma-glutamylcysteine synthetase associated with inflammation and cinod
8) Confidence 0.59 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.10 Pain Relevance 0.20
These mice express lower basal levels of the Nrf2 target genes such as NQO1, GST, GCS, UDP-glucuronosyltransferase, glutathione peroxidase-2, and HO-1 (Chan and Kwong 2000; Cho et al. 2002; Hayes et al. 2000; Kwak et al. 2001; McMahon et al. 2001).
Gene_expression (express) of GCS
9) Confidence 0.46 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0.07
These mice express lower basal levels of the Nrf2 target genes such as NQO1, GST, GCS, UDP-glucuronosyltransferase, glutathione peroxidase-2, and HO-1 (Chan and Kwong 2000; Cho et al. 2002; Hayes et al. 2000; Kwak et al. 2001; McMahon et al. 2001).
Gene_expression (express) of GCS
10) Confidence 0.40 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0.07
Expression of another oxidative stress-sensitive gene, gamma-glutamylcysteine synthetase heavy subunit gene (gamma-GCSh), which encodes the rate-limiting enzyme in glutathione biosynthesis, was also induced by sulindac.
Gene_expression (Expression) of gamma-glutamylcysteine synthetase associated with stress
11) Confidence 0.35 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.65 Pain Relevance 0.46
Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.
Gene_expression (expression) of gamma-glutamylcysteine synthetase in colon associated with inflammation, colon cancer, cinod and cox2
12) Confidence 0.31 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11820781 Disease Relevance 0.66 Pain Relevance 0.57
Expression of GCLC, involved in glutathione synthesis, was upregulated after 6 hours (Table 2).
Gene_expression (Expression) of GCLC
13) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.16 Pain Relevance 0
Isothiocyanates induced protein expression of AKR1C1, NAD(P)H:quinone oxidoreductase 1 (NQO1) and heavy subunit of glutamate-cysteine ligase (GCLC) in a colon cancer cell line [43].
Gene_expression (expression) of GCLC in colon associated with glutamate and colon cancer
14) Confidence 0.24 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.19 Pain Relevance 0.05
We measured the transcript levels of NRF2, NQO1, GSR, GCLc, GCLm, MRP1, and MRP2 by real-time RT-PCR.
Gene_expression (levels) of GCLc
15) Confidence 0.21 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.60 Pain Relevance 0
The levels of Nrf2, Keap1, heme oxygenase 1, glutamate-cysteine ligase catalytic subunit (GCLC) and NAD(P)H:quinone oxidoreductase 1 gene expression were determined using 50 ng of cDNA and SYBR Green JumpStart Taq Ready Mix, using GAPDH as an internal standard for normalization.
Spec (determined) Gene_expression (levels) of GCLC in internal associated with glutamate
16) Confidence 0.18 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0.05
The expression profiles of the transcripts of the antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase in both human and mouse oviducts and oocytes have also been examined [16].
Spec (examined) Gene_expression (expression) of gamma-glutamylcysteine synthetase in oocytes
17) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.65 Pain Relevance 0
The expression profiles of the transcripts of the antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase in both human and mouse oviducts and oocytes have also been examined [16].
Spec (examined) Gene_expression (expression) of gamma-glutamylcysteine synthetase in oviducts
18) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.65 Pain Relevance 0

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