INT100938

From wiki-pain
Revision as of 13:21, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 42.11
Pain Relevance 14.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
lung 5
T-cell 3
eosinophils 2
mast cell 2
lymph node 1
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1030 100.00 Very High Very High Very High
Inflammation 1217 99.98 Very High Very High Very High
rheumatoid arthritis 432 99.62 Very High Very High Very High
Paracetamol 20 99.58 Very High Very High Very High
fibrosis 230 99.42 Very High Very High Very High
Arthritis 326 96.84 Very High Very High Very High
Inflammatory response 48 96.84 Very High Very High Very High
chemokine 211 95.76 Very High Very High Very High
antagonist 136 94.28 High High
agonist 39 90.44 High High
Disease Link Frequency Relevance Heat
Hyperplasia 85 100.00 Very High Very High Very High
Targeted Disruption 66 100.00 Very High Very High Very High
INFLAMMATION 1206 99.98 Very High Very High Very High
Candida Infection 139 99.90 Very High Very High Very High
Eosinophilia 56 99.90 Very High Very High Very High
Metaplasia 19 99.88 Very High Very High Very High
Asthma 1209 99.84 Very High Very High Very High
Sprains And Strains 208 99.70 Very High Very High Very High
Rheumatoid Arthritis 432 99.62 Very High Very High Very High
Lymphatic System Cancer 9 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following APAP (200 mg/kg) administration to male C57BL/6 wild-type (WT) mice, hepatotoxicity developed up to 24 h post-APAP, with a concomitant increase in serum IL-13 concentration.
Positive_regulation (increase) of IL-13 associated with paracetamol and hepatotoxicity
1) Confidence 0.69 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17439248 Disease Relevance 0.93 Pain Relevance 0.79
The increased levels of IL-13 mRNA and protein in the sputum of subjects with asthma have been correlated with an increased eosinophil count6 and airway hyper-responsiveness.7 It is generally agreed that many allergic disorders are associated with hypereosinophilia, including asthma and atopic dermatitis.
Positive_regulation (increased) of IL-13 in eosinophil associated with asthma, hypersensitivity and eczema
2) Confidence 0.57 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.22
These functional changes were associated with lymphocytic/eosinophilic inflammation, goblet cell metaplasia, and increased concentrations of IL-5 and IL-13 in the BALF.
Positive_regulation (increased) of IL-13 in goblet cell associated with rhinitis, inflammation and metaplasia
3) Confidence 0.44 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12225955 Disease Relevance 1.04 Pain Relevance 0.25
Chronic OVA challenge induced a similar significant increase in levels of lung IL-5 and IL-13 in Siglec-F deficient and WT mice.
Positive_regulation (increase) of IL-13 in lung
4) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.62 Pain Relevance 0.27
IL-13 is reported to induce eosinophil recruitment into the lung via an IL-5- and eotaxin-dependent mechanism.30 Indeed, several studies have reported that IL-13 induces eotaxin production in epithelial and smooth muscle cells.31,32 In-vivo data have shown that IL-13 stimulates eotaxin in IL-13 transgenic mice.33 The increase in eotaxin-1 levels was proportional to the impaired lung function and bronchial hyper-reactivity in asthmatics, as shown in previous studies.34,35 In this study, we found that the GG genotype of the Arg110Gln (110G>A) polymorphism was associated with a significantly higher eotaxin-1 level, as compared to the AA type; these findings suggest that the 110G allele is associated with eotaxin-1-mediated eosinophilic inflammation.
Positive_regulation (increase) of IL-13 in lung associated with targeted disruption, rhinitis, inflammation and occupational lung diseases
5) Confidence 0.41 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.69 Pain Relevance 0.04
The lower levels of IL-5 and IL-13 observed in the lung are likely a result of decreased recruitment of T cells since CD3+ T cells were seen to be reduced in the lung after H4R antagonist treatment, but not by anti-IL-13 treatment.
Positive_regulation (levels) of IL-13 in T cells associated with antagonist
6) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.67 Pain Relevance 0.30
IL-13 is a critical cytokine in the pathogenesis of allergic asthma in a mouse model of asthma,3 and is involved in several physiological changes, such as airway eosinophilia and hyper-responsiveness.4 In humans, CD4+T cells, eosinophils, mast cells, basophils, and natural killer T cells produce IL-13, inducing IgG4 and IgE synthesis in cultured B cells.5 IL-13 mRNA and protein are increased in the sputum of asthmatics and have been correlated with an increased eosinophil count6 and airway hyper-responsiveness (AHR).7 In addition, the expression of vascular cell adhesion molecule-1 (VCAM-I) is upregulated in endothelial cells, which may contribute to eosinophil migration into airway tissues.8
Positive_regulation (increased) of IL-13 in B cells associated with asthma, occupational lung diseases, adhesions, eosinophilia and cytokine
7) Confidence 0.38 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.76 Pain Relevance 0.36
As such, numerous approaches to blocking increased IL-13 in asthma are being evaluated, with emphasis on IL-13 neutralizing antibodies and soluble receptors, but the identification of oral, small molecule inhibitors of IL-13 would have obvious advantages.
Positive_regulation (increased) of IL-13 associated with asthma
8) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.03 Pain Relevance 0.32
Although IL-13 was also upregulated in this study using the bleomycin model, its expression was at a relatively late stage and occurred after collagen deposition.
Positive_regulation (upregulated) of IL-13
9) Confidence 0.34 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.81 Pain Relevance 0.35
Development of airway hyperreactivity and hyperresponsiveness to innocuous stimuli is a diagnostic and pathological feature of asthma that can be recapitulated in animal models of allergic airway inflammation, and has been linked to increased airway IL-13 [20].
Positive_regulation (increased) of IL-13 associated with asthma, inflammation and hypersensitivity
10) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.10 Pain Relevance 0.26
and IL-13 up-regulated receptor expression at the protein level with a 7 fold and 3.5 fold increase over basal, respectively.
Positive_regulation (up-regulated receptor) of IL-13
11) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.21 Pain Relevance 0.26
As shown in Figure. 3A and 3B, oxytocin (100 nM) induced a rapid increase in intracellular calcium concentration reaching 30 ± 11 nM that was significantly enhanced in IL-13-treated cells to 117 ± 18 nM (n = 9, P < 0.05) (Figure 4).
Positive_regulation (enhanced) of IL-13
12) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.16 Pain Relevance 0.27
It may be that fish oil is able to alter the cytokine milieu towards a more Th2 profile, and hence we saw a 2-fold increase in IL-13 levels.
Positive_regulation (increase) of IL-13 associated with cytokine
13) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2907316 Disease Relevance 1.00 Pain Relevance 0.74
Mouse IL-4, IL-5, IL-13, and IFN-?.
Positive_regulation (Mouse) of IL-13 in Mouse
14) Confidence 0.29 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.13 Pain Relevance 0.12
Th2 cytokines (IL-4, IL-13) were significantly increased from 4 h to day 7. 5-HT-expressing cells in the intestine were increased from day 1 to day 7.
Positive_regulation (increased) of IL-13 in intestine
15) Confidence 0.29 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19735478 Disease Relevance 0.06 Pain Relevance 0
The maximal secretion ranged from as early as 2 - 4 h for TNF-alpha to 8 - 12 h, with a long lasting elevation, for IL-5 and IL-13 [31].
Positive_regulation (ranged) of IL-13
16) Confidence 0.28 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.47 Pain Relevance 0.32
Chronic OVA challenge in WT mice induced a significant increase in lung levels of IL-5 (p < 0.03)(Figure 5A), IL-13 (p < 0.04)(Figure 5B), and eotaxin-1 (p < 0.01)(Figure 5C) compared to WT mice not challenged with OVA.
Positive_regulation (increase) of IL-13 in lung
17) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.10
Because IgE levels in BALF are dependent upon IL-4, IL-5, IL-13 and may be considered
Positive_regulation (dependent) of IL-13
18) Confidence 0.27 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.13
As shown in Figures 4A and 4B, IL-5 and IL-13 levels from OVA-challenged and PBS-treated mice of the positive control group were markedly increased compared to the negative control group (challenged and treated with PBS).
Positive_regulation (increased) of IL-13
19) Confidence 0.26 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.36 Pain Relevance 0.33
was observed [11], [16], [21], [24], it was preceded by a strong and early induction of Th2 transcripts, such as IL-4, IL-5 and IL-13.
Positive_regulation (induction) of IL-13
20) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.78 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox