INT101008

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 57
Disease Relevance 26.93
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn5a) plasma membrane (Scn5a) transmembrane transport (Scn5a)
Anatomy Link Frequency
skeletal muscle 2
ventricles 1
neurons 1
Scn5a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1166 100.00 Very High Very High Very High
nav1.8 1 100.00 Very High Very High Very High
nav1.3 107 99.80 Very High Very High Very High
anesthesia 53 99.50 Very High Very High Very High
Nav1.6 1 99.48 Very High Very High Very High
Nav1.2 1 99.26 Very High Very High Very High
Nav1.1 3 99.10 Very High Very High Very High
Action potential 346 92.64 High High
tetrodotoxin 10 92.32 High High
addiction 111 89.68 High High
Disease Link Frequency Relevance Heat
Fibrosis 1007 100.00 Very High Very High Very High
Aging 530 99.96 Very High Very High Very High
Targeted Disruption 219 99.92 Very High Very High Very High
Disease 212 99.84 Very High Very High Very High
Cardiovascular Disorder Under Development 159 99.28 Very High Very High Very High
Heart Arrhythmia 857 99.12 Very High Very High Very High
Arrhythmias 2 Under Development 1431 98.72 Very High Very High Very High
Body Weight 3 95.84 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 13 93.84 High High
Apoptosis 53 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Gene_expression (expression) of Nav 1.5 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
1) Confidence 0.75 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.59
Because distribution of QRS intervals in the Scn5a+/?
Gene_expression (intervals) of Scn5a
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.60 Pain Relevance 0.19
Taken together, studies in patients and in Scn5a+/?
Gene_expression (studies) of Scn5a
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.64 Pain Relevance 0.05
mice, although this increase was slightly more pronounced in Scn5a+/?
Gene_expression (/) of Scn5a
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.29 Pain Relevance 0
Moreover, among the 25 litters in which all Scn5a+/?
Gene_expression (/) of Scn5a
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.35 Pain Relevance 0
In 2 others, all Scn5a+/?
Gene_expression (/) of Scn5a
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.38 Pain Relevance 0
Reduced Nav1.5 Protein Expression and INa Density in Scn5a+/?
Gene_expression (/) of Scn5a
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0 Pain Relevance 0.12
8; p<0.05 versus WT), 0.60±0.40 in Scn5a+/?
Gene_expression (0.40) of Scn5a
8) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 1.04 Pain Relevance 0.34
Scn5a transcript levels were similar in both groups of Scn5a+/?
Gene_expression (/) of Scn5a
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.16 Pain Relevance 0.05
In contrast, fibrosis in Scn5a+/?
Gene_expression (fibrosis) of Scn5a associated with fibrosis
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 1.10 Pain Relevance 0.30
The two Scn5a+/?
Gene_expression (/) of Scn5a
11) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.33 Pain Relevance 0.03
Phenotype severity in Scn5a+/?
Gene_expression (severity) of Scn5a
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.30 Pain Relevance 0
50% reduction in Nav1.5 protein expression whereas Nav1.5 reduction in mice with a mild phenotype was less pronounced.
Gene_expression (expression) of Nav1.5 protein
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.53 Pain Relevance 0.18
mice with a mild phenotype, i.e. with a small QRS prolongation, and Scn5a+/?
Gene_expression (/) of Scn5a
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.34 Pain Relevance 0
Atrial and atrioventricular conduction (as evaluated respectively by P wave and PR interval durations) were similar in the two groups of Scn5a+/?
Gene_expression (/) of Scn5a
15) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.24 Pain Relevance 0
In young Scn5a+/?
Gene_expression (/) of Scn5a
16) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0 Pain Relevance 0.12
We investigated the mechanisms of this heterogeneity in a mouse model with heterozygous targeted disruption of Scn5a (Scn5a+/?
Gene_expression (/) of Scn5a associated with targeted disruption
17) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824822 Disease Relevance 0.60 Pain Relevance 0
We then investigated Nav1.5 protein expression.
Spec (investigated) Gene_expression (expression) of Nav1.5 protein
18) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0 Pain Relevance 0.12
Because distribution of QRS intervals in the Scn5a+/?
Gene_expression (/) of Scn5a
19) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.55 Pain Relevance 0.19
-subunit (Kcne1 gene) overexpression in Scn5a+/?
Gene_expression (/) of Scn5a
20) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.21 Pain Relevance 0.12

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