INT101055

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.39
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIN2B) plasma membrane (GRIN2B)
Anatomy Link Frequency
forebrain 1
GRIN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 15 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
allodynia 1 99.68 Very High Very High Very High
Pain 7 99.16 Very High Very High Very High
Neuropathic pain 6 99.12 Very High Very High Very High
Lasting pain 5 99.12 Very High Very High Very High
Glutamate 2 94.04 High High
IPN 1 93.04 High High
Glutamate receptor 3 89.20 High High
Anterior cingulate cortex 1 66.76 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 99.68 Very High Very High Very High
Pain 8 99.12 Very High Very High Very High
Nervous System Injury 1 94.44 High High
Inflammatory Pain 1 93.04 High High
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The following review provides a summary of recent findings regarding the structural features, localization, functional properties, and regulation of the NR2B subunit.
Regulation (regulation) of NR2B
1) Confidence 0.61 Published 2003 Journal Pharmacol. Ther. Section Abstract Doc Link 12493535 Disease Relevance 0.09 Pain Relevance 0.17
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain.
Regulation (Targeting) of NR2B associated with neuralgia, nmda receptor and neuropathic pain
2) Confidence 0.26 Published 2009 Journal Neurotherapeutics Section Title Doc Link 19789073 Disease Relevance 0.77 Pain Relevance 1.31
The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.
Regulation (regulation) of NR2B associated with pain and nmda receptor
3) Confidence 0.23 Published 2003 Journal Pharmacol. Ther. Section Title Doc Link 12493535 Disease Relevance 0.07 Pain Relevance 0.27
Drugs targeting NMDA NR2B subunits in the forebrain could serve as a new class of medicine for controlling persistent pain in humans.
Regulation (targeting) of NR2B in forebrain associated with pain and lasting pain
4) Confidence 0.15 Published 2002 Journal Drug Discov. Today Section Abstract Doc Link 11839523 Disease Relevance 0.46 Pain Relevance 0.76

General Comments

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