INT101065

Context Info Confidence 0.43 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 1.02

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

MAP3K15 (Homo sapiens) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 13 98.64

Disease Link Frequency Relevance Heat Apoptosis 2 100.00 Stress 2 79.68 Colon Cancer 1 69.28 INFLAMMATION 1 52.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mobility on SDS-PAGE of the apoptosis signal-regulating kinase, which activates C-Jun N-terminal kinases and p38 MAPK cascades, was reduced by H(2)O(2) and NSAIDs, suggesting, that H(2)O(2) and NSAIDs activated apoptosis signal-regulating kinase by increasing its state of phosphorylation.

apoptosis signal-regulating kinase Positive_regulation (activates) of C-Jun associated with cinod and apoptosis

1) Confidence 0.43 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.46 Pain Relevance 1.02

General Comments

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