INT101104

Context Info Confidence 0.69 First Reported 2001 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 5.87 Pain Relevance 1.09

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)

Anatomy Link Frequency tendon cell 2 PSCs 2 tendon 2 COL1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 17 99.64 Inflammation 77 90.92 Inflammatory mediators 5 90.48 Osteoarthritis 91 89.84 fibrosis 9 77.16 Chronic pancreatitis 2 73.84 anesthesia 1 61.76 metalloproteinase 21 50.56 cytokine 31 42.88 cINOD 3 16.76

Disease Link Frequency Relevance Heat Hypoxia 15 99.98 Obesity 109 94.76 Rupture 4 94.16 Tendinopathy 9 92.40 Cirrhosis 9 92.40 Arthritis 4 90.92 INFLAMMATION 80 90.48 Osteoarthritis 96 89.84 Aging 18 89.44 Death 1 86.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, suitable dosages of LLLI may result in more effective tissue healing by promoting type I collagen and decorin synthesis.

Positive_regulation (promoting) of Gene_expression (synthesis) of type I collagen

1) Confidence 0.69 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.11 Pain Relevance 0.08

Hypoxia induced migration, type I collagen expression, and vascular endothelial growth factor (VEGF) production in PSCs.

Positive_regulation (induced) of Gene_expression (expression) of type I collagen in PSCs associated with hypoxia

2) Confidence 0.36 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.61 Pain Relevance 0.19

RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.

Positive_regulation (induces) of Gene_expression (expression) of type I collagen

3) Confidence 0.21 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0

At older ages (60–80 years), there is increased denaturation of Type II collagen and a small increase in the synthesis of Type I procollagen.

Positive_regulation (increase) of Gene_expression (synthesis) of procollagen

4) Confidence 0.11 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.45 Pain Relevance 0.07

The downstream targets of leptin identified in the current study are in agreement with those previously published because IGF-1, type 2 collagen and MMP-13 were overexpressed upon leptin stimulation [9-12].

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of type 2 collagen

5) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.56 Pain Relevance 0.38

In this context, it should be noted that the chondrogenic differentiation of MPCs mediated by PPS was demonstrated without the addition of growth factors or other chondroinductive supplements and failed to upregulate type I collagen and collagen type X expression.

Neg (failed) Positive_regulation (upregulate) of Gene_expression (expression) of type I collagen

6) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0

There is increased expression of the COL1A1 gene, which encodes for the alpha1 chain of type I collagen, in the painful Achilles tendon.

Positive_regulation (increased) of Gene_expression (expression) of type I collagen in tendon associated with pain

7) Confidence 0.06 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.62 Pain Relevance 0.10

Histological analyses revealed significant increase in cellular components and type I collagen expression in all transplants using IL-6-retained hydrogel as compared to hydrogel only (Figures 6B and 6C).

Positive_regulation (increase) of Gene_expression (expression) of type I collagen

8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.36 Pain Relevance 0.04

As type I collagen is the most abundant protein of the osteoid, we finally investigated whether gal-3 affects expression of the type I collagen ?

Positive_regulation (abundant) of Gene_expression (is) of type I collagen

9) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.19 Pain Relevance 0.09

In situ hybridization studies showed an increase of the type I procollagen mRNA expression mainly in portal tracts and septa.

Positive_regulation (increase) of Gene_expression (expression) of type I procollagen mRNA

10) Confidence 0.03 Published 2001 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 11846091 Disease Relevance 0.58 Pain Relevance 0.06

Anitua et al. showed that in vitro VEGF and Hepatocyte Growth Factor (HGF) considerably increased following exposure to the pool of released growth factors; suggesting they accelerate tendon cell proliferation and stimulate type I collagen synthesis [11].

Positive_regulation (stimulate) of Gene_expression (synthesis) of type I collagen in tendon cell

11) Confidence 0.03 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682411 Disease Relevance 0.32 Pain Relevance 0.08

Furthermore, EGCG inhibited ethanol-induced type-I procollagen production and collagen secretion.

Positive_regulation (induced) of Gene_expression (production) of procollagen

12) Confidence 0.00 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0

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