INT101104

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.87
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
tendon cell 2
PSCs 2
tendon 2
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 17 99.64 Very High Very High Very High
Inflammation 77 90.92 High High
Inflammatory mediators 5 90.48 High High
Osteoarthritis 91 89.84 High High
fibrosis 9 77.16 Quite High
Chronic pancreatitis 2 73.84 Quite High
anesthesia 1 61.76 Quite High
metalloproteinase 21 50.56 Quite High
cytokine 31 42.88 Quite Low
cINOD 3 16.76 Low Low
Disease Link Frequency Relevance Heat
Hypoxia 15 99.98 Very High Very High Very High
Obesity 109 94.76 High High
Rupture 4 94.16 High High
Tendinopathy 9 92.40 High High
Cirrhosis 9 92.40 High High
Arthritis 4 90.92 High High
INFLAMMATION 80 90.48 High High
Osteoarthritis 96 89.84 High High
Aging 18 89.44 High High
Death 1 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, suitable dosages of LLLI may result in more effective tissue healing by promoting type I collagen and decorin synthesis.
Positive_regulation (promoting) of Gene_expression (synthesis) of type I collagen
1) Confidence 0.69 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.11 Pain Relevance 0.08
Hypoxia induced migration, type I collagen expression, and vascular endothelial growth factor (VEGF) production in PSCs.
Positive_regulation (induced) of Gene_expression (expression) of type I collagen in PSCs associated with hypoxia
2) Confidence 0.36 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.61 Pain Relevance 0.19
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Positive_regulation (induces) of Gene_expression (expression) of type I collagen
3) Confidence 0.21 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
At older ages (60–80 years), there is increased denaturation of Type II collagen and a small increase in the synthesis of Type I procollagen.
Positive_regulation (increase) of Gene_expression (synthesis) of procollagen
4) Confidence 0.11 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.45 Pain Relevance 0.07
The downstream targets of leptin identified in the current study are in agreement with those previously published because IGF-1, type 2 collagen and MMP-13 were overexpressed upon leptin stimulation [9-12].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of type 2 collagen
5) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.56 Pain Relevance 0.38
In this context, it should be noted that the chondrogenic differentiation of MPCs mediated by PPS was demonstrated without the addition of growth factors or other chondroinductive supplements and failed to upregulate type I collagen and collagen type X expression.
Neg (failed) Positive_regulation (upregulate) of Gene_expression (expression) of type I collagen
6) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
There is increased expression of the COL1A1 gene, which encodes for the alpha1 chain of type I collagen, in the painful Achilles tendon.
Positive_regulation (increased) of Gene_expression (expression) of type I collagen in tendon associated with pain
7) Confidence 0.06 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.62 Pain Relevance 0.10
Histological analyses revealed significant increase in cellular components and type I collagen expression in all transplants using IL-6-retained hydrogel as compared to hydrogel only (Figures 6B and 6C).
Positive_regulation (increase) of Gene_expression (expression) of type I collagen
8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.36 Pain Relevance 0.04
As type I collagen is the most abundant protein of the osteoid, we finally investigated whether gal-3 affects expression of the type I collagen ?
Positive_regulation (abundant) of Gene_expression (is) of type I collagen
9) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.19 Pain Relevance 0.09
In situ hybridization studies showed an increase of the type I procollagen mRNA expression mainly in portal tracts and septa.
Positive_regulation (increase) of Gene_expression (expression) of type I procollagen mRNA
10) Confidence 0.03 Published 2001 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 11846091 Disease Relevance 0.58 Pain Relevance 0.06
Anitua et al. showed that in vitro VEGF and Hepatocyte Growth Factor (HGF) considerably increased following exposure to the pool of released growth factors; suggesting they accelerate tendon cell proliferation and stimulate type I collagen synthesis [11].
Positive_regulation (stimulate) of Gene_expression (synthesis) of type I collagen in tendon cell
11) Confidence 0.03 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682411 Disease Relevance 0.32 Pain Relevance 0.08
Furthermore, EGCG inhibited ethanol-induced type-I procollagen production and collagen secretion.
Positive_regulation (induced) of Gene_expression (production) of procollagen
12) Confidence 0.00 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0

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