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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 63
Total Number 69
Disease Relevance 34.75
Pain Relevance 26.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
brain 5
hippocampus 3
tail 2
hypothalamus 2
proximal 2
Comt (Mus musculus)
Comt - V158M (1)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 1838 100.00 Very High Very High Very High
Catecholamine 155 100.00 Very High Very High Very High
Nucleus accumbens 608 99.92 Very High Very High Very High
Morphine 1027 99.80 Very High Very High Very High
tail-flick 18 99.50 Very High Very High Very High
Pain 561 99.48 Very High Very High Very High
anesthesia 20 99.32 Very High Very High Very High
Hippocampus 322 99.10 Very High Very High Very High
Lasting pain 115 98.84 Very High Very High Very High
amygdala 86 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 3478 99.74 Very High Very High Very High
Urological Neuroanatomy 184 99.68 Very High Very High Very High
Pain 703 99.48 Very High Very High Very High
Disease 162 98.64 Very High Very High Very High
Nociception 37 98.52 Very High Very High Very High
Schizophrenia 166 98.30 Very High Very High Very High
Cognitive Disorder 260 98.28 Very High Very High Very High
Anxiety Disorder 922 98.04 Very High Very High Very High
Alcohol Addiction 4 97.68 Very High Very High Very High
Manic Depressive Disorder 52 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these diverse mapping data sets demonstrate that expression of Comt is strongly cis-regulated and is caused by sequence variation in or around Comt itself.
Gene_expression (expression) of Comt
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.45 Pain Relevance 0.03
UTR is associated with higher levels of COMT protein expression.


Gene_expression (expression) of COMT protein associated with catechol-o-methyltransferase
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.39 Pain Relevance 0.17
Similarly, strains with higher Comt1 expression due to the presence of a B2 SINE insertion were reported to be less sensitive to nociceptive stimuli.
Gene_expression (expression) of Comt1 associated with nociception and sprains and strains
3) Confidence 0.75 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2958038 Disease Relevance 0.90 Pain Relevance 0.10
In summary, changes in Comt1 expression altered many different behaviors in mice but the directionality of these differences was only somewhat similar to what has been observed in humans.
Gene_expression (expression) of Comt1
4) Confidence 0.75 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2958038 Disease Relevance 0.73 Pain Relevance 0.07
We first noted that in those studies of whole brain homogenates, Comt expression was significantly decreased in DBA, as compared to C57, consistent with our studies in the NAC.
Gene_expression (expression) of Comt in brain associated with nucleus accumbens and catechol-o-methyltransferase
5) Confidence 0.75 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.23 Pain Relevance 1.14
The expression of Comt in this family of strains varies over 2-fold in several CNS regions and is strongly modulated by a polymorphism located within Comt itself [13].
Gene_expression (expression) of Comt associated with sprains and strains
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.56 Pain Relevance 0.20
We examined Comt expression in multiple tissues in over 100 diverse strains and several genetic crosses.
Spec (examined) Gene_expression (expression) of Comt associated with sprains and strains
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.34 Pain Relevance 0.19
In this family, Comt expression maps to the location of the Comt gene itself (Fig. 1C and Fig. 1D).
Gene_expression (expression) of Comt
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.51 Pain Relevance 0.07
UTR length that segregates among BXD strains and is the sole cause of cis-regulation of Comt expression.
Gene_expression (expression) of Comt associated with sprains and strains
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.41 Pain Relevance 0.06
We mapped this variation in Comt expression in several crosses, including the large BXD family.
Gene_expression (expression) of Comt
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.59 Pain Relevance 0.07
We measured expression of Comt across multiple tissues in over 100 strains of mice and several large F2 intercrosses using four microrray platforms.
Gene_expression (expression) of Comt associated with sprains and strains
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.74 Pain Relevance 0.09
Given the marked differences in expression of Comt covariates in different tissues and organs, we neither expected nor did we find significant overlap of its downstream targets.
Gene_expression (expression) of Comt
12) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.22
All crosses derived from strains that differed in Comt expression show strong cis-modulation.
Gene_expression (expression) of Comt associated with sprains and strains
13) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.48 Pain Relevance 0.04
The genetic mechanism of the observed variation in Comt expression has been an unresolved question.
Gene_expression (expression) of Comt
14) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.75 Pain Relevance 0.14
The B2 SINE is associated with higher expression of Comt coding exons in B6 relative to D2 in the cerebellum, hippocampus, and striatum but not in the prefrontal cortex, ventral tegmental area, and nucleus accumbens.
Gene_expression (expression) of Comt in cerebellum associated with nucleus accumbens, ventral tegmentum and hippocampus
15) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.53 Pain Relevance 0.14
Conversely, overexpression of human COMT containing the Val polymorphism in mice leads to the disruption of working memory and attention and a reduction in sensitivity to pain and stress [30].
Gene_expression (overexpression) of COMT associated with stress, pain and catechol-o-methyltransferase
16) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.59 Pain Relevance 0.42
This is the first known variant in mice that causes variation in Comt expression.
Gene_expression (expression) of Comt
17) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.84 Pain Relevance 0.09
Profound differences in Comt expression were detected among highly diverse inbred strains of mice (Figure S1, Figure S2).
Gene_expression (expression) of Comt associated with sprains and strains
18) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.41 Pain Relevance 0.05
In summary, Comt expression level is about 2-fold higher in C57BL/6J than in the other mouse strains, though hypothetical longer transcript form is more abundant in DBA/2J, 129P3/J and SWR/J strains (Figure 3B).
Gene_expression (expression) of Comt associated with catechol-o-methyltransferase and sprains and strains
19) Confidence 0.66 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.72 Pain Relevance 0.31
Five genes (Atp1a2, Comt, Gabra1, Gabra2 and Syt4) were selected for a qPCR experiment since they were linked by GO analysis to synaptic transmission (GO:0007268).
Gene_expression (experiment) of Comt associated with catechol-o-methyltransferase
20) Confidence 0.66 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.22 Pain Relevance 0.25

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