INT10117

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Context Info
Confidence 0.43
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.71
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
plasma 2
platelet 2
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 13 99.84 Very High Very High Very High
addiction 5 92.40 High High
Opioid 3 92.00 High High
opiate 4 90.12 High High
antidepressant 3 84.72 Quite High
headache 1 77.24 Quite High
monoamine 1 57.52 Quite High
analgesia 1 25.00 Low Low
withdrawal 1 25.00 Low Low
Neurotransmitter 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 6 100.00 Very High Very High Very High
Depression 14 99.84 Very High Very High Very High
Suicidal Behaviour 6 99.32 Very High Very High Very High
Disease 26 99.28 Very High Very High Very High
Mental Disorders 6 98.40 Very High Very High Very High
Endometroid Carcinoma 21 97.52 Very High Very High Very High
Neurodegenerative Disease 3 93.52 High High
Opiate Addiction 3 92.40 High High
Carcinoma 61 90.16 High High
Endometrial Cancer 153 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FCs observed for a subset of the genes have been confirmed with additional qRT-PCR results (Table 2 and Table 3)

Protein expression of the Insulin Receptor (IR) and PGC1?

Positive_regulation (results) of Insulin Receptor
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0 Pain Relevance 0
These findings are consistent with a pituitary source for the elevated plasma beta E IR found during late pregnancy which may, in turn, be a consequence of elevated plasma concentrations of placentally secreted plasma corticotropin-releasing factor IR present during the third trimester.
Positive_regulation (elevated) of E IR in plasma
2) Confidence 0.36 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1464647 Disease Relevance 0 Pain Relevance 0.09
These findings are consistent with a pituitary source for the elevated plasma beta E IR found during late pregnancy which may, in turn, be a consequence of elevated plasma concentrations of placentally secreted plasma corticotropin-releasing factor IR present during the third trimester.
Positive_regulation (elevated) of factor IR in plasma
3) Confidence 0.33 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1464647 Disease Relevance 0 Pain Relevance 0.09
However, evidence also has accumulated for the relevance of IR and an endogenous ligand, agmatine, to psychiatric disease.
Positive_regulation (relevance) of IR associated with mental disorders
4) Confidence 0.22 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028565 Disease Relevance 0.10 Pain Relevance 0.03
The level of I2-IR in glial tumors is increased (two-fivefold) in parallel with the abundance of the related 29/30-kD IR protein (39%), whereas the level of 45-kD IR protein is decreased (39%).
Positive_regulation (increased) of IR associated with glioma
5) Confidence 0.16 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.99 Pain Relevance 0.23
In depression, the level of a 45-kD IR protein (putative I1-IR) is increased in the brain of suicide victims (51%) and in platelets of depressed patients (40%).
Positive_regulation (increased) of IR in platelets associated with suicidal behaviour and depression
6) Confidence 0.16 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.81 Pain Relevance 0.31
ins, for instance those binding multiple insulin molecules, is that they do not drastically change the model predictions, but only distribute the IR?
Neg (not) Positive_regulation (distribute) of IR
7) Confidence 0.15 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
There were no differences between the IR-MPH (tid) and the OROS-MPH groups with the exception of a smaller increase in pulse in OROS-MPH group that, although statistically significant (p = 0.049), would be of limited clinical significance.
Positive_regulation (increase) of IR-MPH
8) Confidence 0.13 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2075491 Disease Relevance 0.84 Pain Relevance 0.16
The density of platelet I1-IR ([125I]-p-iodoclonidine binding) is also increased in depression (135%).
Positive_regulation (increased) of IR in platelet associated with depression
9) Confidence 0.11 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.97 Pain Relevance 0.31
Westin and colleague [14] described that expression of estrogen-induced genes, RALDH2, EIG121, SFRP1, SFRP4, IGF-1, and IGF-IR, tend to be highest in the well-to-moderately differentiated endometrioid carcinoma.
Positive_regulation (induced) of IGF-IR associated with endometroid carcinoma
10) Confidence 0.02 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.99 Pain Relevance 0

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