INT101193

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Context Info
Confidence 0.22
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.62
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
spinal cord 3
neck 2
neurons 2
PaG 1
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 220 100.00 Very High Very High Very High
antinociception 24 100.00 Very High Very High Very High
Spinal cord 16 100.00 Very High Very High Very High
tolerance 13 99.36 Very High Very High Very High
Locus ceruleus 30 99.20 Very High Very High Very High
Neuropathic pain 4 98.88 Very High Very High Very High
Raphe 8 98.28 Very High Very High Very High
IPN 13 97.32 Very High Very High Very High
medulla 20 96.88 Very High Very High Very High
Antinociceptive 12 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 265 100.00 Very High Very High Very High
Targeted Disruption 46 99.52 Very High Very High Very High
Neuropathic Pain 8 98.88 Very High Very High Very High
Sleep Disorders 120 98.28 Very High Very High Very High
Inflammatory Pain 13 97.32 Very High Very High Very High
Nociception 32 96.72 Very High Very High Very High
Anxiety Disorder 62 95.84 Very High Very High Very High
Pain 52 95.68 Very High Very High Very High
Pressure Volume 2 Under Development 4 95.64 Very High Very High Very High
Parkinson's Disease 4 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In present investigation, we demonstrate for the first time that changes in NMDARs expression in the PAG is selective for NR2B subunits, not NR2A ones.
Regulation (changes) of Gene_expression (expression) of PAG associated with central grey
1) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.02 Pain Relevance 1.24
Effect of HCRT2-SAP lesions of the vlPAG on sleep in FVB-GFP mice
Regulation (Effect) of Gene_expression (lesions) of vlPAG
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0 Pain Relevance 0.10
Experiment 2: vlPAG lesions in FVB-GFP transgenic mice
Regulation (Experiment) of Gene_expression (lesions) of vlPAG associated with targeted disruption
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.28 Pain Relevance 0.04
What is the activity of vlPAG neurons during wake, non-REM sleep, REM sleep and cataplexy?
Regulation (activity) of Gene_expression (neurons) of vlPAG in neurons associated with sleep disorders
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.76 Pain Relevance 0.06
deltorphin into the PAG did not produce antinociception regardless of how
Neg (not) Regulation (regardless) of Neg (not) Gene_expression (produce) of PAG associated with antinociception and urological neuroanatomy
5) Confidence 0.21 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 1.09 Pain Relevance 0.95
Subsequent study revealed that a persistent (inescapable) noxious cutaneous manipulation (clip of the neck) evoked both selective ventrolateral PAG Fos expression and passive emotional coping.
Regulation (ventrolateral) of Gene_expression (expression) of PAG in neck associated with urological neuroanatomy
6) Confidence 0.17 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 11856974 Disease Relevance 1.46 Pain Relevance 1.09
encroaching upon this latter PAG region do not seem to affect the motivational
Regulation (latter) of Gene_expression (region) of PAG associated with central grey
7) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.51 Pain Relevance 0.26
cells was found in the ventrolateral part of the PAG (Figure 2(n)).At rostral pontine levels, a few
Regulation (ventrolateral) of Gene_expression (part) of PAG associated with central grey
8) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.24 Pain Relevance 0.25
PAG (i.e., the dorsomedial and ventrolateral parts) and in the intermediate
Regulation (ventrolateral) of Gene_expression (parts) of PAG associated with central grey
9) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.15 Pain Relevance 0.16
Conversely, the down-regulated P2X3 receptor expression in the lPAG with antisense oligodeoxynucleotide (ODN) for P2X3 gene significantly attenuated the antinociceptive effect of EA treatment.
Regulation (regulated) of Gene_expression (expression) of lPAG associated with electroacupuncture and antinociceptive
10) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 1.17 Pain Relevance 1.54
this effect by intra-dlPAG administration of AEA and AM404 in rats submitted to
Regulation (effect) of Gene_expression (administration) of dlPAG
11) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.80 Pain Relevance 0.39
Overall, the results show distinct changes in Fos expression in the spinal cord and PaG of 6OHDA-lesioned rats, suggesting a substrate for some of the abnormal sensory (nociceptive) circuits that may be evident in parkinsonian cases.
Regulation (changes) of Gene_expression (expression) of PaG in spinal cord associated with parkinson's disease, nociception and spinal cord
12) Confidence 0.01 Published 2008 Journal Int. J. Neurosci. Section Abstract Doc Link 18576208 Disease Relevance 0.57 Pain Relevance 0.35
Overall, the results show distinct changes in Fos expression in the spinal cord and PaG of 6OHDA-lesioned rats, suggesting a substrate for some of the abnormal sensory (nociceptive) circuits that may be evident in parkinsonian cases.
Regulation (changes) of in PaG Gene_expression (expression) of PaG in spinal cord associated with parkinson's disease, nociception and spinal cord
13) Confidence 0.00 Published 2008 Journal Int. J. Neurosci. Section Abstract Doc Link 18576208 Disease Relevance 0.57 Pain Relevance 0.35

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