INT101240

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2008
Negated 6
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.04
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
cardiomyocytes 2
nucleus 2
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 6 98.08 Very High Very High Very High
cytokine 16 94.52 High High
Paracetamol 6 94.48 High High
addiction 4 85.36 High High
cINOD 4 75.00 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Thoracotomy 4 5.00 Very Low Very Low Very Low
Acupuncture 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 7 99.76 Very High Very High Very High
Cirrhosis 57 98.80 Very High Very High Very High
Skin Cancer 12 93.44 High High
Fibrosis 13 90.12 High High
Squamous Cell Neoplasms 4 79.12 Quite High
INFLAMMATION 5 75.00 Quite High
Cancer 8 74.00 Quite High
Hypertrophy 24 71.92 Quite High
Chronic Hepatitis 31 69.48 Quite High
Hepatitis 33 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although our previous work both in 48 h PO myocardium and in RGD-stimulated adult cardiomyocytes3, 4 demonstrates c-Src recruitment and activation, expression of DNSrc in cardiomyocytes in the 3D environment did not affect the RGD-stimulated STAT3 phosphorylation.
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of STAT3 in cardiomyocytes
1) Confidence 0.57 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
This HCV-induced up regulation of STAT3 phosphorylation was shown before in man and rodent models in vivo as well as in vitro studies on cell-lines [24,25].
Regulation (regulation) of Phosphorylation (phosphorylation) of STAT3 associated with hepatitis c virus infection
2) Confidence 0.49 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.37 Pain Relevance 0.05
The sulfone metabolite of sulindac, which lacks cyclooxygenase-inhibitory activity, did not affect either Stat3 expression or Stat3 phosphorylation.
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Stat3
3) Confidence 0.45 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.72 Pain Relevance 0.14
When we examined STAT3 under these conditions (Figure 3c), both RGD-stimulated recruitment to the insoluble fraction and phosphorylation of STAT3 were unaffected by DNSrc overexpression.
Neg (unaffected) Regulation (unaffected) of Phosphorylation (phosphorylation) of STAT3
4) Confidence 0.42 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Finally, we focused on the possible role of a TEC family member, BMX, in STAT3 phosphorylation.
Spec (possible) Regulation (role) of Phosphorylation (phosphorylation) of STAT3
5) Confidence 0.42 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
In the same cell type neither IL-1beta-dependent SAPK activation nor IL-6-induced STAT3 phosphorylation is affected by the drug.
Neg (neither) Regulation (affected) of Phosphorylation (phosphorylation) of STAT3
6) Confidence 0.40 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.48
The sulfone metabolite of sulindac, which lacks cyclooxygenase-inhibitory activity, did not affect either Stat3 expression or Stat3 phosphorylation.
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Stat3
7) Confidence 0.27 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.72 Pain Relevance 0.14
However, v-Src-transformation of NIH 3T3 cells results in constitutive STAT3 phosphorylation which is unaffected by JAK inhibitors.36 A recent study35 has suggested that the mechanism by which this occurs is through more rapid cycling of “activated” STAT3 between the nucleus and cytoplasm than “non-activated” STAT3.
Neg (unaffected) Regulation (unaffected) of Phosphorylation (phosphorylation) of STAT3 in nucleus
8) Confidence 0.25 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.23 Pain Relevance 0.07

General Comments

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