INT10136

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 11.18
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
plasma 4
endothelial cells 1
arterioles 1
proximal 1
skin 1
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 99.80 Very High Very High Very High
lidocaine 1 99.70 Very High Very High Very High
imagery 20 99.38 Very High Very High Very High
Angina 19 99.36 Very High Very High Very High
cytokine 22 99.28 Very High Very High Very High
aspirin 18 97.32 Very High Very High Very High
cva 14 96.96 Very High Very High Very High
cINOD 5 96.24 Very High Very High Very High
adenocard 15 93.92 High High
Arthritis 9 93.76 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 60 99.84 Very High Very High Very High
Adenoma 3 99.84 Very High Very High Very High
INFLAMMATION 77 99.80 Very High Very High Very High
Thrombosis 34 99.80 Very High Very High Very High
Shock 10 99.54 Very High Very High Very High
Cv General 3 Under Development 24 99.36 Very High Very High Very High
Pancreatic Cancer 5 99.16 Very High Very High Very High
Cancer 75 98.84 Very High Very High Very High
Carcinoma 7 98.68 Very High Very High Very High
Necrosis 11 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A dose-dependent inhibition of IL-1beta and TPA stimulated MMP activity by gallium nitrate at increasing concentrations occurs, demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis.
Negative_regulation (inhibition) of TPA associated with inflammation and arthritis
1) Confidence 0.42 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 16122880 Disease Relevance 1.81 Pain Relevance 0.78
Migraineurs NO3- and ET-1 plasma levels, compared to control values, showed a significant decrease and increase respectively; fibrinogen, beta-TG and D-dimer appeared slightly lowered in migraineurs, while Htc remained in the normal limits; tPA, PAI-1 and FI were significantly reduced, while fibrinopeptide A, blood viscosity and plasma viscosity at a low shear rate (shr) exhibited a significant rise.
Negative_regulation (reduced) of tPA in plasma
2) Confidence 0.41 Published 1996 Journal Artery Section Abstract Doc Link 8864251 Disease Relevance 0.16 Pain Relevance 0.24
Streptokinase and rt-PA produced similar reductions in mortality in the recent GISSI-2 and International t-PA/Streptokinase Mortality trials, findings which may be further clarified by ongoing comparative trials such as ISIS-3.
Negative_regulation (reductions) of t-PA
3) Confidence 0.41 Published 1990 Journal Drugs Section Abstract Doc Link 2191849 Disease Relevance 0.29 Pain Relevance 0.13
Furthermore, in shock conditions, levels of t-PA inhibition were high in both the non-leukopenic and leukopenic groups [27].
Negative_regulation (inhibition) of t-PA associated with shock
4) Confidence 0.40 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.74 Pain Relevance 0
PAI-1 represent the most important physiological inhibitor of tissue-type plasminogen activator (TPA) in plasma and elevated levels have been implicated in the pathogenesis of thromboembolic disease (Ridker 1992).
Negative_regulation (inhibitor) of TPA in plasma associated with cva
5) Confidence 0.40 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.42 Pain Relevance 0.13
PAI-1 represent the most important physiological inhibitor of tissue-type plasminogen activator (TPA) in plasma and elevated levels have been implicated in the pathogenesis of thromboembolic disease (Ridker 1992).
Negative_regulation (inhibitor) of tissue-type plasminogen activator in plasma associated with cva
6) Confidence 0.40 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.42 Pain Relevance 0.13
In AB and EF groups RBC velocity increased significantly in arterioles during reperfusion in comparison with I/R (p < 0.05, Figs. 1,2) whereas it further increased in either groups treated with t-PA in combination with gpIIa/IIIb inhibitors (tAB: 42% and tEF: 46% vs. the AB and EF groups, respectively, p < 0.05).


Negative_regulation (treated) of t-PA in arterioles
7) Confidence 0.40 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.09 Pain Relevance 0.04
g/100 g infused intravenously); the fifth group (tAB, n = 6) was treated with t-PA plus abciximab (50 plus 0.6 ?
Negative_regulation (treated) of t-PA
8) Confidence 0.40 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.16 Pain Relevance 0.10
In contrast tissue plasminogen activator activity was reduced in adenomas (P less than 0.01) and carcinomas, levels being significantly lower in carcinomas (P less than 0.01).
Negative_regulation (reduced) of tissue plasminogen activator associated with adenoma and carcinoma
9) Confidence 0.33 Published 1987 Journal Br J Surg Section Abstract Doc Link 3111578 Disease Relevance 1.04 Pain Relevance 0.07
To the best of our knowledge no other studies have associated tPA markers with PTB; however, several studies have observed increased tPA and tissue factors expression in preterm compared to term human decidual tissues [34], [35]. tPA is a serine protease inhibitor in the fibrynolitic cascade (Figure 2) that converts inactive plasminogen to plasmin.
Negative_regulation (inhibitor) of tPA
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.31 Pain Relevance 0.08
In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC.
Negative_regulation (inhibited) of TPA in skin associated with lidocaine
11) Confidence 0.24 Published 1984 Journal Anticancer Res. Section Abstract Doc Link 6517531 Disease Relevance 0 Pain Relevance 0.27
Patients with unstable angina and coronary thrombus (n = 45) received alteplase through an infusion catheter at the proximal aspect of the target lesion and concomitant intracoronary heparin via a standard guiding catheter.
Negative_regulation (received) of alteplase in proximal associated with angina and thrombosis
12) Confidence 0.19 Published 1996 Journal Cathet Cardiovasc Diagn Section Abstract Doc Link 8721695 Disease Relevance 0.76 Pain Relevance 0.27
plasminogen activator (tPA) was decreased by RGZ treatment in pancreatic tumor
Negative_regulation (decreased) of tPA associated with pancreatic cancer
13) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.89 Pain Relevance 0
," instead asking students such questions as the sensitivity and specificity of imaging modalities, the absolute risk reduction of tPA in thrombotic stroke, and the applicability of evidence to a particular patient.
Negative_regulation (reduction) of tPA associated with cv unclassified under development and imagery
14) Confidence 0.17 Published 2007 Journal Osteopath Med Prim Care Section Body Doc Link PMC1808469 Disease Relevance 0.10 Pain Relevance 0.05
The actions of TPA were blocked by pretreatment with the selective PKC inhibitor bisindolylmaleimide, but not by inhibition of protein synthesis with cycloheximide or anisomycin.
Negative_regulation (blocked) of TPA
15) Confidence 0.16 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.07 Pain Relevance 0
After receiving a single bolus alteplase 50 mg IV (Actilyse® Boehringer Ingelheim GmbH), a loading dose of aspirin 500 mg, and heparin 5000 IU in the ambulance according to the prehospital thrombolysis protocol, patients, following oral informed consent, are randomized to undergo 15 minutes of pulsatile ultrasound with intravenous administration of ultrasound contrast agent or placebo without ultrasound.
Negative_regulation (receiving) of alteplase associated with aspirin
16) Confidence 0.12 Published 2008 Journal Trials Section Abstract Doc Link PMC2614934 Disease Relevance 0.26 Pain Relevance 0.05
In the fibrinolytic pathway, C1-inhibitor participates in the inactivation of plasmin and tissue plasminogen activator (tPA).
Negative_regulation (inactivation) of tPA
17) Confidence 0.08 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.44 Pain Relevance 0.07
Of these, plasminogen activator inhibitor-1 (PAI-1) is considered to be the main inhibitor of t-PA in the vascular compartments, Additionally, ?
Negative_regulation (inhibitor) of t-PA
18) Confidence 0.06 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 0.54 Pain Relevance 0.10
At the same time plasminogen activator inhibitor (PAI-1) is also released from endothelial cells by ATP stimulation, in turn inhibiting t-PA.
Negative_regulation (inhibiting) of t-PA in endothelial cells
19) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.38 Pain Relevance 0.11
The study was undertaken to evaluate the effect of antifibrinolytic agents (epsilon-aminocaproic acid, EACA; tranexamic acid, AMCA), anti-inflammatory drugs (indomethacin, IND; ibuprofen, IBU; naproxen, NAP) and root extract of the plant Boerhaavia diffusa (BD) on menstrual cycle length (MCL), duration of menstrual flow (DMF), menstrual iron loss (MIL) and activity of uterine tissue plasminogen activator (tPA) in IUD-fitted monkeys.
Negative_regulation (loss) of tissue plasminogen activator in uterine associated with inflammation and cinod
20) Confidence 0.04 Published 1991 Journal Adv Contracept Section Abstract Doc Link 1908176 Disease Relevance 0.23 Pain Relevance 0.15

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