INT101368

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.61
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC3) transport (ASIC3) plasma membrane (ASIC3)
cytoplasm (ASIC3)
Anatomy Link Frequency
sensory neurons 2
neuron 2
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 99.98 Very High Very High Very High
Nerve growth factor 18 99.82 Very High Very High Very High
Kinase C 5 98.98 Very High Very High Very High
hyperexcitability 2 98.40 Very High Very High Very High
Hyperalgesia 4 97.04 Very High Very High Very High
ASIC 60 95.24 Very High Very High Very High
dorsal root ganglion 2 93.72 High High
tissue acidosis 4 90.56 High High
sodium channel 25 88.96 High High
Pain 7 88.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.98 Very High Very High Very High
Nociception 2 97.56 Very High Very High Very High
Hyperalgesia 4 97.04 Very High Very High Very High
Ganglion Cysts 4 93.72 High High
Acidosis 16 90.56 High High
Pain 7 88.28 High High
Inflammatory Pain 4 81.44 Quite High
Death 24 60.52 Quite High
Ageusia 16 50.00 Quite Low
Toxicity 18 22.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed that low endogenous NGF was responsible for ASIC3 basal expression and high NGF during inflammation increased ASIC3 expression parallely to the development of neuron hyperexcitability associated with hyperalgesia.
Positive_regulation (increased) of Gene_expression (expression) of ASIC3 in neuron associated with hyperalgesia, inflammation, nerve growth factor and hyperexcitability
1) Confidence 0.32 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.70 Pain Relevance 1.03
Detection of a shorter fragment of ASIC1a (461 bp) with primers HASIC3 and HASIC4, also yielded negative results even after 50 cycles (Figure 1, Lane C).
Positive_regulation (fragment) of Gene_expression (Detection) of HASIC3
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.09
CIPP is thus a scaffolding protein that could both enhance the surface expression of ASIC3 and bring together ASIC3 and functionally related proteins in the membrane of sensory neurons.
Positive_regulation (enhance) of Gene_expression (expression) of ASIC3 in sensory neurons
3) Confidence 0.23 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.45 Pain Relevance 0.24
NGF controls ASIC3 basal expression through constitutive activation of a trkA/phospholipase C/protein kinase C pathway, (ii). high inflammatory-like NGF induces ASIC3 overexpression through a trkA/JNK/p38MAPK pathway and a p75-dependent mechanism as a transcriptional switch, and (iii).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ASIC3 associated with kinase c, inflammation and nerve growth factor
4) Confidence 0.22 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.64 Pain Relevance 1.05
Co-expression of CIPP and ASIC3 in COS cells increases the maximal ASIC3 peak current density by a factor of 5 and slightly shifts the pH(0.5) for activation from pH 6.2 to pH 6.4.
Positive_regulation (increases) of Gene_expression (expression) of ASIC3
5) Confidence 0.21 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.48 Pain Relevance 0.32
This potentiation is also likely due to increased surface expression of ASIC3.
Positive_regulation (increased) of Gene_expression (expression) of ASIC3
6) Confidence 0.16 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.11 Pain Relevance 0.11
A multivalent PDZ domain containing-protein CIPP (channel-interacting PDZ domain protein) was found to interact with ASIC3 and overexpression of CIPP potentials ASIC3-mediated currents [48].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ASIC3
7) Confidence 0.16 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.12 Pain Relevance 0.11
This potentiation is also likely due to increased surface expression of ASIC3.
Positive_regulation (increased) of Gene_expression (expression) of ASIC3
8) Confidence 0.12 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.11 Pain Relevance 0.11

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