INT101369

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.11
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC3) transport (ASIC3) plasma membrane (ASIC3)
cytoplasm (ASIC3)
Anatomy Link Frequency
plasma 1
sensory neurons 1
spinal cord 1
chest 1
dorsal root ganglia 1
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 6 100.00 Very High Very High Very High
Angina 1 99.76 Very High Very High Very High
ischemia 1 98.32 Very High Very High Very High
Spinal cord 8 97.92 Very High Very High Very High
Serotonin 2 95.64 Very High Very High Very High
Mechanosensation 4 94.04 High High
nociceptor 4 93.72 High High
dorsal root ganglion 1 91.96 High High
bradykinin 1 90.80 High High
Pain 7 90.64 High High
Disease Link Frequency Relevance Heat
Angina 1 99.76 Very High Very High Very High
Coronary Artery Disease 1 98.64 Very High Very High Very High
Nociception 5 95.80 Very High Very High Very High
Ganglion Cysts 2 91.96 High High
INFLAMMATION 2 84.96 Quite High
Hyperalgesia 1 74.88 Quite High
Pain 3 74.20 Quite High
Acidosis 2 71.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ASIC3 and these interacting proteins were expressed in dorsal root ganglia and spinal cord, and PSD-95 co-precipitated ASIC3 from spinal cord.
ASIC3 Binding (interacting) of in spinal cord associated with spinal cord
1) Confidence 0.32 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.38
The finding that multiple PDZ-containing proteins bind ASIC3 and can influence its presence in the plasma membrane suggests that they may play an important role in the contribution of ASIC3 to nociception and mechanosensation.
ASIC3 Binding (bind) of in plasma associated with nociception and mechanosensation
2) Confidence 0.32 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0.09 Pain Relevance 0.33
We found that a PDZ-binding motif at the ASIC3 C terminus interacts with four different proteins that contain PDZ domains: PSD-95, Lin-7b, MAGI-1b, and PIST.
ASIC3 Binding (interacts) of
3) Confidence 0.24 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.35
CIPP is thus a scaffolding protein that could both enhance the surface expression of ASIC3 and bring together ASIC3 and functionally related proteins in the membrane of sensory neurons.
ASIC3 Binding (bring) of in sensory neurons
4) Confidence 0.17 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.44 Pain Relevance 0.24
ASIC3 and these interacting proteins were expressed in dorsal root ganglia and spinal cord, and PSD-95 co-precipitated ASIC3 from spinal cord.
ASIC3 Binding (interacting) of in dorsal root ganglia associated with spinal cord
5) Confidence 0.11 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.38
An analysis of the promoter region of the ASIC3 encoding gene, an ASIC specifically expressed in sensory neurons and associated with chest pain that accompanies cardiac ischemia, reveals that gene transcription is controlled by NGF and serotonin.
ASIC3 Binding (associated) of in chest associated with angina, coronary artery disease, ischemia, serotonin and asic
6) Confidence 0.07 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486159 Disease Relevance 0.58 Pain Relevance 0.82

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