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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 159
Total Number 169
Disease Relevance 104.77
Pain Relevance 25.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 12
fat 9
neurons 7
hip 6
placenta 5
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 125 100.00 Very High Very High Very High
Osteoarthritis 2509 99.70 Very High Very High Very High
Hippocampus 192 99.60 Very High Very High Very High
tolerance 121 99.50 Very High Very High Very High
addiction 45 99.28 Very High Very High Very High
nMDA receptor 611 98.90 Very High Very High Very High
long-term potentiation 323 98.76 Very High Very High Very High
Inflammatory mediators 38 98.76 Very High Very High Very High
cocaine 295 98.56 Very High Very High Very High
fluoxetine 10 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 8061 100.00 Very High Very High Very High
Body Weight 560 100.00 Very High Very High Very High
Disseminated Intravascular Coagulation 153 100.00 Very High Very High Very High
Hyperglycemia 57 100.00 Very High Very High Very High
Peripheral Arterial Disease 32 100.00 Very High Very High Very High
Corneal Neovascularization 37 99.98 Very High Very High Very High
Anxiety Disorder 219 99.96 Very High Very High Very High
Hypercapnia 60 99.88 Very High Very High Very High
Osteophyte 180 99.84 Very High Very High Very High
Adhesions 46 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin (5HT) has satiety effects similar to those of leptin and alters LH release, and serotonergic neurons, which have been shown to express leptin receptors, terminate on GnRH neurons.
Gene_expression (express) of leptin in neurons associated with 5ht and serotonin
1) Confidence 0.78 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 12021050 Disease Relevance 0 Pain Relevance 0.30
Leptin is a permissive metabolic signal for reproduction, but GnRH neurons do not appear to express leptin receptors, suggesting that interneurons transmit leptin signals to these cells.
Gene_expression (express) of leptin in interneurons
2) Confidence 0.78 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 12021050 Disease Relevance 0 Pain Relevance 0.22
In an
               effort to better understand the pathophysiology of human obesity, several rodent
               models of obesity have been developed and implemented including high fat diet
               feeding and spontaneous mutants of the 16 KD obesity gene product leptin or its
               receptor such as ob/ob and
                   db/db mice. 
Gene_expression (product) of leptin in fat associated with obesity
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.68 Pain Relevance 0
There is evidence that the regulation of leptin expression through environmental, genetic, or epigenetic factors may be responsible for influencing the production of proinflammatory mediators and matrix metalloproteinases in cartilage [47].
Gene_expression (expression) of leptin in cartilage associated with metalloproteinase
4) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.65 Pain Relevance 0.26
Adipose tissue is the primary source of leptin production, and at the final time point the serum leptin concentrations per unit fat mass were 1.75 ± 0.30 ng/ml/g, 4.18 ± 0.67 ng/ml/g, and 4.39 ± 0.44 ng/ml/g fat for control mice, LG mice, and HG mice, respectively.
Gene_expression (production) of leptin in fat associated with obesity
5) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.54 Pain Relevance 0.38
Osteoarthritis increases the expression of leptin and leptin receptors in chondrocytes [49], suggesting that physiologic levels of leptin may mediate the production of inflammatory mediators in osteoarthritic but not normal tissue.
Gene_expression (expression) of leptin in chondrocytes associated with inflammatory mediators and osteoarthritis
6) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.65 Pain Relevance 0.25
Osteoarthritis increases the expression of leptin and leptin receptors in chondrocytes [49], suggesting that physiologic levels of leptin may mediate the production of inflammatory mediators in osteoarthritic but not normal tissue.
Gene_expression (expression) of leptin in chondrocytes associated with inflammatory mediators and osteoarthritis
7) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.60 Pain Relevance 0.23
However, leptin receptors are widely expressed in many brain regions including the hippocampus, cerebellum, brain stem and amygdala (Hakansson et al., 1998; Elmquist et al., 1998a; Shanley et al., 2002), suggesting that leptin plays a role in diverse CNS functions.
Gene_expression (expressed) of leptin in brain stem associated with hippocampus and amygdala
8) Confidence 0.74 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.13 Pain Relevance 0.29
In contrast, in neurons with reduced leptin receptor expression, the ability of leptin (50 nM; 30 min) to alter the density of dendritic filopodia was significantly reduced such that the mean density of filopodia was 1.37 ± 0.15 (n = 36) and 1.48 ± 0.13 (n = 36; P > 0.05) in the absence and presence of leptin, respectively.
Gene_expression (expression) of leptin in neurons
9) Confidence 0.74 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
During neuronal development, leptin also plays a pivotal role: leptin receptors are expressed at high levels in neonatal rodent brains (Morash et al., 2001), and reductions in brain weight and protein content are evident in leptin-deficient or -insensitive rodents (Ahima et al., 1999).
Gene_expression (expressed) of leptin in neuronal
10) Confidence 0.74 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.32 Pain Relevance 0.38
These data suggest that the alterations in dendritic morphology induced by leptin are mediated by activation of leptin receptors as genetic knockdown of leptin receptor expression in hippocampal neurons markedly attenuated the effects of this hormone.
Gene_expression (expression) of leptin in neurons
11) Confidence 0.74 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
The expression of leptin and leptin receptors has been demonstrated on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells [40].

2.2.

Gene_expression (expression) of leptin in mast cells
12) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.16 Pain Relevance 0.04
The leptin receptor Ob-Rb is expressed by B and T lymphocytes, suggesting that leptin regulates directly the B and T cell responses [10].
Gene_expression (expressed) of leptin in T cell
13) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.39 Pain Relevance 0.04
The expression of leptin and leptin receptors has been demonstrated on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells [40].

2.2.

Gene_expression (expression) of leptin in mast cells
14) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.16 Pain Relevance 0.04
The need for costimulation with mitogens to get the effect of leptin in lymphocytes may be partly explained by this effect of activation, increasing leptin receptor expression in T lymphocytes.
Gene_expression (expression) of leptin in T lymphocytes
15) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0 Pain Relevance 0.11
In summary, this study indicates that selective leptin resistance in agouti obese mice occurs with central neural administration of leptin, suggesting that selective leptin resistance in this model is not due to a defect in leptin transport across the blood brain barrier.
Gene_expression (resistance) of leptin in brain associated with obesity
16) Confidence 0.68 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.76 Pain Relevance 0.30
In summary, this study indicates that selective leptin resistance in agouti obese mice occurs with central neural administration of leptin, suggesting that selective leptin resistance in this model is not due to a defect in leptin transport across the blood brain barrier.
Gene_expression (resistance) of leptin in brain associated with obesity
17) Confidence 0.68 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.86 Pain Relevance 0.32
Here, we examined whether selective leptin resistance exists in agouti mice during central neural administration of leptin.
Spec (whether) Gene_expression (resistance) of leptin in neural
18) Confidence 0.68 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.62 Pain Relevance 0.22
We recently demonstrated that in a rodent model of obesity (agouti yellow mice), there is a selective leptin resistance with preservation of the sympathetic actions despite loss of appetite and weight-reducing actions of systemic leptin.
Gene_expression (resistance) of leptin in sympathetic associated with obesity and anorexia
19) Confidence 0.68 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.48 Pain Relevance 0.14
Leptin can be produced within the knee joint [16,40], and concentrations of leptin in synovial fluid have been observed to be similar to or even higher than those in serum [23,40], suggesting leptin may have a local influence on the joint.
Gene_expression (produced) of Leptin in joint
20) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.54 Pain Relevance 0.12

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