INT101549

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.82
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EMP1) plasma membrane (EMP1)
EMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 6 97.48 Very High Very High Very High
Potency 6 96.36 Very High Very High Very High
tramadol 6 94.80 High High
Pain 1 92.72 High High
Bioavailability 2 9.24 Low Low
Dysuria 3 5.00 Very Low Very Low Very Low
pain flank 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Prostatitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 97.20 Very High Very High Very High
Cystitis 7 96.96 Very High Very High Very High
Arthralgia 1 92.72 High High
Sacroiliitis 1 91.08 High High
Hypercalcemia 1 91.04 High High
Rickets 3 88.76 High High
Hypophosphatemia 5 84.32 Quite High
Disease 4 81.76 Quite High
Pyelonephritis 52 76.24 Quite High
Infection 17 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All 15 cases had normal serum creatinine, normocalcemia, normal 1,25-dihydroxyvitamin D (1,25-(OH)2D), reduced serum phosphate concentration, reduced urinary calcium excretion and reduced TmP/GFR.
Negative_regulation (reduced) of TmP
1) Confidence 0.57 Published 2002 Journal Acta Paediatr Taiwan Section Abstract Doc Link 11890223 Disease Relevance 0.97 Pain Relevance 0.09
Hydrophobic acidic (diclofenac, indomethacin, ibuprofen and ketoprofen) or neutral (n-hexane, anthracene, o-xylene and toluene) compounds could not instead inhibit TMP, indicating a stringent requirement for drug basicity in the pharmacological inhibition of TMP.
Negative_regulation (inhibit) of TMP associated with diclofenac
2) Confidence 0.51 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17531203 Disease Relevance 0.06 Pain Relevance 0.18
TMP was also inhibited by other hydrophobic cationic amphiphiles without radical-scavenging activity, namely desethylamiodarone, chlorpromazine, clomipramine, promethazine, promazine, verapamil, bromhexine, propranolol, mepivacaine, metoprolol, tramadol and ranitidine, whose anti-TMP potency was far lower than that of amiodarone and related to drug hydrophobicity degree.
Negative_regulation (inhibited) of TMP associated with tramadol and potency
3) Confidence 0.51 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17531203 Disease Relevance 0.09 Pain Relevance 0.17
In fact, a recent study found that fluoroquinolones had replaced TMP/SMX nationwide as the preferred first-line antimicrobial for uncomplicated cystitis (Kallen et al 2006).
Negative_regulation (replaced) of TMP associated with cystitis
4) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621400 Disease Relevance 0.48 Pain Relevance 0
Hydrophobic acidic (diclofenac, indomethacin, ibuprofen and ketoprofen) or neutral (n-hexane, anthracene, o-xylene and toluene) compounds could not instead inhibit TMP, indicating a stringent requirement for drug basicity in the pharmacological inhibition of TMP.
Negative_regulation (inhibition) of TMP associated with diclofenac
5) Confidence 0.38 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17531203 Disease Relevance 0.06 Pain Relevance 0.17
Further, TMP was strongly inhibited by butylhydroxytoluene, a lipophilic radical scavenger.
Negative_regulation (inhibited) of TMP
6) Confidence 0.38 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17531203 Disease Relevance 0.07 Pain Relevance 0.19
In conclusions, primarily drug basicity and then hydrophobicity are solely relevant to TMP inhibition.
Negative_regulation (inhibition) of TMP
7) Confidence 0.38 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17531203 Disease Relevance 0 Pain Relevance 0.12
The drug, albeit devoid of specific radical-scavenging effects, inhibited TMP at therapeutic concentrations and with an efficiency similar to that of the physiological co-antioxidant ascorbic acid, showing indeed an IC(50) of 5microM.
Negative_regulation (inhibited) of TMP
8) Confidence 0.38 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17531203 Disease Relevance 0.10 Pain Relevance 0.09

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