INT101612

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Context Info
Confidence 0.86
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
body 2
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 51.60 Quite High
peripheral neuropathy 2 25.00 Low Low
tolerance 2 25.00 Low Low
Substantia nigra 2 10.96 Low Low
Inflammation 13 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 4 97.72 Very High Very High Very High
Stress 15 97.32 Very High Very High Very High
Disease 51 92.40 High High
Neurodegenerative Disease 9 88.72 High High
Refractory Anemia 2 84.12 Quite High
Oral Lichen Planus 2 80.32 Quite High
Death 27 50.00 Quite Low
Chorea 1 43.96 Quite Low
Movement Disorders 2 43.56 Quite Low
Dermatophyte Infection 2 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Benarroch 2009; Bishop et al. 2010a; Brown 2009a; Friedman et al. 2007; Jellinger 1999; Ke and Qian 2003; Kell 2009a; Lee et al. 2006a; Perez and Franz 2010; Thompson et al. 2001; Youdim et al. 2004b; Zecca et al. 2004), and the question arises as to whether huntingtin (or, more likely, its degradation fragments), containing these polyQ tracts, can catalyse oxidative stress and/or hydroxyl formation directly.
Protein_catabolism (degradation) of huntingtin associated with stress
1) Confidence 0.86 Published 2010 Journal Arch Toxicol Section Body Doc Link PMC2988997 Disease Relevance 0.40 Pain Relevance 0
On post-PBSCT day 68 he developed acute cutaneous GvHD grade 3 and acute gastrointestinal GvHD grade 2-3, which was resolved with a daily dose of 1 mg/kg of body weight of prednisone.
Protein_catabolism (grade) of GvHD in body associated with body weight
2) Confidence 0.02 Published 2002 Journal Int. J. Dermatol. Section Abstract Doc Link 11895513 Disease Relevance 0.52 Pain Relevance 0
On post-PBSCT day 68 he developed acute cutaneous GvHD grade 3 and acute gastrointestinal GvHD grade 2-3, which was resolved with a daily dose of 1 mg/kg of body weight of prednisone.
Protein_catabolism (grade) of GvHD in body associated with body weight
3) Confidence 0.02 Published 2002 Journal Int. J. Dermatol. Section Abstract Doc Link 11895513 Disease Relevance 0.52 Pain Relevance 0.05

General Comments

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