INT10162

Context Info Confidence 0.40 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 3.37 Pain Relevance 3.68

extracellular space (Gpx3) oxidoreductase activity (Gpx3) extracellular region (Gpx3)

Anatomy Link Frequency extracellular matrix 2 nucleus accumbens 1 sciatic nerve 1 MCF-7 1 striatum 1 Gpx3 (Mus musculus)

Pain Link Frequency Relevance Heat Analgesic 1 100.00 Dopamine 10 99.96 Morphine 14 99.82 Pain 2 99.68 fibrosis 56 99.50 Nucleus accumbens 8 99.28 Sciatic nerve 4 98.88 Glutamate 24 98.24 Neuropathic pain 2 97.72 Hippocampus 5 94.36

Disease Link Frequency Relevance Heat Pain 2 99.68 Pulmonary Fibrosis 29 99.50 Sprains And Strains 11 99.12 Hypertrophy 3 98.10 Neuropathic Pain 2 97.72 Attention Deficit Hyperactivity Disorder 2 97.52 Fibrosis 44 96.92 Penetrating Head Injuries 5 96.20 Hyperhomocysteinemia 2 92.04 Neurological Disease 1 90.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, in dorsal striatum the morphine-induced increase of extracellular DA was lower in DBA/2J mice than in C57BL/6J.

Positive_regulation (increase) of extracellular in striatum associated with dopamine and morphine

1) Confidence 0.40 Published 2005 Journal Synapse Section Abstract Doc Link 15700287 Disease Relevance 0.35 Pain Relevance 1.20

In the nucleus accumbens, morphine (20 mg/kg) significantly increased extracellular levels of DA in both strains.

Positive_regulation (increased) of extracellular in nucleus accumbens associated with nucleus accumbens, dopamine, sprains and strains and morphine

2) Confidence 0.40 Published 2005 Journal Synapse Section Abstract Doc Link 15700287 Disease Relevance 0.37 Pain Relevance 1.20

Thirty women in their third trimester of pregnancy (37-42 weeks), 40 women during and 72 h after labour and 18 non-pregnant controls were studied for changes in serum and mononuclear cell cation content, and their relationship to cervical effacement and intensity of pain as measured by plasma beta endorphin concentrations during labour.

Positive_regulation (concentrations) of plasma beta in mononuclear cell associated with pain

3) Confidence 0.09 Published 1992 Journal Magnes Res Section Abstract Doc Link 1467154 Disease Relevance 0.10 Pain Relevance 0.10

Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.

Positive_regulation (Activation) of extracellular in sciatic nerve associated with analgesic, neuropathic pain and sciatic nerve

4) Confidence 0.02 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19762761 Disease Relevance 0.19 Pain Relevance 0.55

In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.

Positive_regulation (induction) of extracellular in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries

5) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.96 Pain Relevance 0.18

Lung fibrosis is characterized by the accumulation of extracellular matrix proteins, such as collagen III.

Positive_regulation (accumulation) of extracellular in extracellular matrix associated with fibrosis and pulmonary fibrosis

6) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.70 Pain Relevance 0.26

Here we show an activation of the extracellular signal-regulated kinases (ERK1 and ERK2) and the downstream nuclear targets Elk-1 and calcium/cAMP response element binding protein, in the hippocampus of cystathionine beta synthase deficient mice, a murine model of hyperhomocysteinemia.

Positive_regulation (activation) of extracellular in hippocampus associated with hippocampus and hyperhomocysteinemia

7) Confidence 0.01 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.27 Pain Relevance 0.20

This is reflected by a substantial increase in the levels of extracellular clusterin (Figure 1 panel B), however since it is not possible to normalize the levels of extracellular clusterin, it is only possible to state that the transfected cell line secretes approximately 10-15 times more clusterin than the untransfected, unstressed MCF-7 cells.

Positive_regulation (increase) of extracellular in MCF-7

8) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.05 Pain Relevance 0

appeared to be concentration-dependent, where the lowest concentration (500 pM) produced no significant increase, 5 nM produced an approximately half-maximal ~37% increase and 500 nM produced a maximal significant ~64% increase in extracellular A?

Positive_regulation (increase) of extracellular

9) Confidence 0.01 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.38 Pain Relevance 0

Analysis of the expression differences between purified and non-purified CMs revealed considerable downregulation of early mesodermal and homeobox genes, and upregulation of cardiovascular and structural genes such as actins and extracellular collagens.

Positive_regulation (upregulation) of extracellular

10) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.