INT101645

Context Info Confidence 0.36 First Reported 2002 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 5.27 Pain Relevance 2.05

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1) cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)

Anatomy Link Frequency retina 2 brain 2 hippocampus 2 MDA-MB-231 2 Bcl2l1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 11 100.00 dexamethasone 43 99.92 fluoxetine 2 99.82 Hippocampus 2 99.68 ischemia 110 99.24 Inflammation 19 97.52 amygdala 5 92.16 antidepressant 4 82.80 depression 1 69.08 cytokine 17 57.24

Disease Link Frequency Relevance Heat Apoptosis 247 100.00 Death 42 99.92 Retina Disease 51 99.24 Breast Cancer 4 99.24 Endometriosis (extended) 1 98.20 INFLAMMATION 24 97.52 Cv General 4 Under Development 15 97.52 Convulsion 4 95.20 Injury 18 92.16 Stress 34 89.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of apoptosis-related molecules, such as Bcl-xS, Bax, and caspase-3, seems to be little regulated in the early stage of this vessel remodeling process.

Neg (little) Regulation (regulated) of Gene_expression (Expression) of Bcl-xS associated with apoptosis

1) Confidence 0.36 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.74 Pain Relevance 0

The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.

Neg (neither) Regulation (regulated) of Gene_expression (ratios) of Bcl-xL associated with apoptosis and death

2) Confidence 0.32 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07

Fluoxetine did not influence Bcl-xl expression in the hippocampus, but it was the only ADT that decreased Bax expression in this region.

Neg (not) Regulation (influence) of Gene_expression (expression) of Bcl-xl in hippocampus associated with hippocampus and fluoxetine

3) Confidence 0.21 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.98 Pain Relevance 0.66

Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-xL expression rather than modifications in Bak and Bcl-2 Purpose

Regulation (alteration) of Gene_expression (expression) of Bcl-xL associated with ischemia, apoptosis and retina disease

4) Confidence 0.19 Published 2009 Journal Molecular Vision Section Title Doc Link PMC2765238 Disease Relevance 0.94 Pain Relevance 0.24

This suggests that modification in Bcl-xL expression after I/R in the retina could be identical to that following cerebral ischemia.

Regulation (modification) of Gene_expression (expression) of Bcl-xL in retina associated with cv general 4 under development and ischemia

5) Confidence 0.17 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.45 Pain Relevance 0.05

Instead, Dex up-regulated the expression of Bcl-XL, IAP-2 and XIAP, while the transcript levels of the anti-apoptotic proteins Bcl-2, IAP-1, FLIPLong and FLIPShort were unaltered by Dex treatment.

Regulation (regulated) of Gene_expression (expression) of Bcl-XL associated with apoptosis and dexamethasone

6) Confidence 0.12 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.55 Pain Relevance 0.27

Such treatment also minimizes apoptotic cell death by influencing STAT-3 phosphorylation and Bcl-xL expression in the brain.

Regulation (influencing) of Gene_expression (expression) of Bcl-xL in brain associated with apoptosis and death

7) Confidence 0.09 Published 2010 Journal Journal of Neuroinflammation Section Abstract Doc Link PMC3022819 Disease Relevance 0.69 Pain Relevance 0.19

Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.

Regulation (effects) of Gene_expression (expression) of bcl-xL in MDA-MB-231 associated with paracetamol, endometriosis (extended) and breast cancer

8) Confidence 0.02 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.37 Pain Relevance 0.56

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