INT10174

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ns5atp9) nucleus (Ns5atp9)
Anatomy Link Frequency
blood 2
Ns5atp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 93.20 High High
Inflammation 18 90.36 High High
antagonist 3 89.84 High High
tetrodotoxin 1 84.08 Quite High
Hyperalgesia 3 81.12 Quite High
Serotonin 1 71.52 Quite High
IPN 1 62.40 Quite High
anesthesia 2 25.00 Low Low
Hyperesthesia 1 25.00 Low Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 4 99.98 Very High Very High Very High
Leukopenia 1 93.56 High High
Pain 1 93.20 High High
Nociception 1 91.80 High High
INFLAMMATION 20 90.36 High High
Necrosis 4 87.40 High High
Cancer 4 87.04 High High
Adhesions 21 85.68 High High
Shock 5 75.68 Quite High
Asthma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hyperalgesic response to PAF was specifically inhibited by agents that interfere with the lipoxygenase pathway of arachidonic acid metabolism and was not affected by cyclooxygenase inhibitors.
Negative_regulation (inhibited) of Positive_regulation (response) of PAF associated with hyperalgesia
1) Confidence 0.40 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2822047 Disease Relevance 0.53 Pain Relevance 0.43
To investigate the interaction between PAF, TNF-alpha and myocardial depressant factor, the blood levels of these three mediators were evaluated: shocked rats exhibited increased PAF levels with a peak at 30 min.
Negative_regulation (exhibited) of Positive_regulation (increased) of PAF in blood
2) Confidence 0.40 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1468489 Disease Relevance 0.69 Pain Relevance 0.03
These responses to PAF occurred only when experiments were conducted at or before approximately 9 A.M.
Negative_regulation (occurred) of Positive_regulation (responses) of PAF
3) Confidence 0.30 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2597284 Disease Relevance 0 Pain Relevance 0.20
The histograms, in Figure 4A, show the increase in fluorescence intensity over the control responses upon the addition of PAF, as well as the inhibitory effect of feG on PAF enhancement of CD11b antibody binding.
Negative_regulation (effect) of Positive_regulation (enhancement) of PAF
4) Confidence 0.04 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.19 Pain Relevance 0

General Comments

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