INT101829

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.61
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 97.36 Very High Very High Very High
Inflammation 9 71.32 Quite High
Glutamate 5 59.36 Quite High
palliative 4 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 424 99.60 Very High Very High Very High
Malignant Neoplastic Disease 16 97.16 Very High Very High Very High
Apoptosis 29 94.24 High High
Non-small-cell Lung Cancer 96 93.40 High High
Stress 41 88.52 High High
Adenocarcinoma 30 87.48 High High
Lung Cancer 218 85.04 High High
INFLAMMATION 11 71.32 Quite High
Carcinoma 4 53.48 Quite High
Carcinoma In Situ 4 51.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, simultaneous treatment with NAC inhibited both indomethacin-induced release of Nrf2 from KIAA0132 and indomethacin-induced nuclear translocation of Nrf2.
Positive_regulation (induced) of Localization (translocation) of Nrf2
1) Confidence 0.67 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.10
Indirect immunofluorescence using intact cells demonstrated that indomethacin induced the nuclear translocation of Nrf2, a transcription factor believed to regulate GCLC expression.
Positive_regulation (induced) of Localization (translocation) of Nrf2
2) Confidence 0.67 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.06 Pain Relevance 0.13
Cancer cells demonstrated increased nuclear localization of NRF2 in comparison with normal cells (Figures 4A–4C and S4).
Positive_regulation (increased) of Localization (localization) of NRF2 associated with cancer
3) Confidence 0.66 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.82 Pain Relevance 0
Upon induction, Nrf2 is stabilized because of impaired Keap1-E3 ubiquitin ligase activity, which results in activation of the Nrf2 signaling pathway (Cullinan et al. 2004; Furukawa and Xiong 2005; Kobayashi et al. 2004; Sun et al. 2007; Zhang et al. 2004b).
Positive_regulation (induction) of Localization (stabilized) of Nrf2
4) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0 Pain Relevance 0
Phosphorylation of NRF2 by protein kinase(s) associated with the MAPK/ERK signaling cascade increases stabilization of NRF2 and has been proposed as an important mechanism leading to increased expression of ARE-dependent genes [11].
Positive_regulation (increases) of Localization (stabilization) of NRF2
5) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.42 Pain Relevance 0.07
In the absence of functional KEAP1 activity, cancer cells demonstrated an increased nuclear accumulation of NRF2 as well as an increase in total NRF2.
Positive_regulation (increased) of Localization (accumulation) of NRF2 associated with cancer
6) Confidence 0.44 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.14 Pain Relevance 0
In the absence of functional KEAP1 activity, cancer cells demonstrated an increased nuclear accumulation of NRF2 as well as an increase in total NRF2.
Positive_regulation (accumulation) of Localization (accumulation) of NRF2 associated with cancer
7) Confidence 0.44 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.08 Pain Relevance 0
Finally, simultaneous treatment with NAC inhibited both indomethacin-induced release of Nrf2 from KIAA0132 and indomethacin-induced nuclear translocation of Nrf2.
Positive_regulation (indomethacin-induced) of Localization (release) of Nrf2
8) Confidence 0.42 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
Nrf2 stabilization was induced by exposure of cells to 50 ?
Positive_regulation (induced) of Localization (stabilization) of Nrf2
9) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.08 Pain Relevance 0

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