INT101875

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.19
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC4R) signal transducer activity (MC4R)
Anatomy Link Frequency
TM4 2
MC4R (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 16 99.28 Very High Very High Very High
antagonist 19 98.00 Very High Very High Very High
Potency 2 97.92 Very High Very High Very High
melanocortin 1 receptor 7 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 2 87.40 High High
Obesity 2 53.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These modeling studies have putatively identified hAGRP ligand DArg111-mMC4RAsn115 (TM3) and the hAGRP DPhe113-mMC4RPhe176 (TM4) interactions as important for agonist activity.
MC4R Binding (interactions) of in TM4 associated with agonist
1) Confidence 0.47 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 15615519 Disease Relevance 0.05 Pain Relevance 0.44
The second and third extracellular loops of MC4R are important for AGRP 87-132 N-terminal binding, whereas the third and fourth transmembrane domains of hMC4R are crucial for AGRP 110-117 binding.
MC4R Binding (binding) of
2) Confidence 0.45 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.07
The second and third extracellular loops of MC4R are important for AGRP 87-132 N-terminal binding, whereas the third and fourth transmembrane domains of hMC4R are crucial for AGRP 110-117 binding.
hMC4R Binding (binding) of
3) Confidence 0.39 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.06
These modeling studies have putatively identified hAGRP ligand DArg111-mMC4RAsn115 (TM3) and the hAGRP DPhe113-mMC4RPhe176 (TM4) interactions as important for agonist activity.
MC4R Binding (interactions) of in TM4 associated with agonist
4) Confidence 0.36 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 15615519 Disease Relevance 0.05 Pain Relevance 0.44
Our previous studies have suggested that in addition to exoloops 2 and 3, several transmembrane domains of MC4R may be important for AGRP binding.
MC4R Binding (binding) of
5) Confidence 0.33 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.12
However, the molecular basis of the interaction between hMC4R and SHU9119 has not been clearly defined.
hMC4R Binding (interaction) of
6) Confidence 0.32 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11912210 Disease Relevance 0.09 Pain Relevance 0.26
This report provides the details of the molecular recognition of SHU9119 antagonism at hMC4R and shows that amino acid Leu(133) of hMC4R plays a key role in melanocortin receptor subtype specificity.
hMC4R Binding (recognition) of
7) Confidence 0.30 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11912210 Disease Relevance 0 Pain Relevance 0.34

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