INT102074

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 13.66
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
liver 6
plasma 2
colon 2
T cell 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 36 98.24 Very High Very High Very High
cytokine 49 97.94 Very High Very High Very High
Inflammation 135 97.74 Very High Very High Very High
cva 30 91.32 High High
agonist 12 75.16 Quite High
cINOD 22 71.04 Quite High
epidural 2 69.84 Quite High
anesthesia 7 69.12 Quite High
Inflammatory response 14 60.68 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 417 100.00 Very High Very High Very High
Pneumonia 48 100.00 Very High Very High Very High
Death 13 99.90 Very High Very High Very High
Hepatocellular Cancer 205 99.84 Very High Very High Very High
Hepatitis Virus Infection 16 99.84 Very High Very High Very High
Thrombosis Related Under Development 13 99.36 Very High Very High Very High
Liver Cancer 40 98.52 Very High Very High Very High
Sepsis 23 98.40 Very High Very High Very High
Colon Cancer 65 98.04 Very High Very High Very High
INFLAMMATION 169 97.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The truncated or functionally inactive APC protein which can result from (1) transcriptional silencing through promoter methylation, (2) a point mutation of the APC gene or (3) loss of heterozygosity (LOH) (Hiltunen et al. 1997; Chen et al. 2005) loses the ability to interact with ?
Positive_regulation (result) of Gene_expression (protein) of APC associated with familial adenomatous polyposis
1) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.45 Pain Relevance 0
The level of APC protein expression was significantly reduced in HCC samples compared to that of the corresponding non-tumor liver tissue (p<0.05).


Positive_regulation (level) of Gene_expression (expression) of APC in liver associated with cancer and hepatocellular cancer
2) Confidence 0.47 Published 2007 Journal J Cancer Res Clin Oncol Section Abstract Doc Link PMC2757596 Disease Relevance 1.06 Pain Relevance 0
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Positive_regulation (responsible) of Gene_expression (expression) of APC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
3) Confidence 0.47 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0
Furthermore, we show that methylation of the APC promoter is also present in the vast majority of the non-tumorous liver tissue samples, indicating that this low level of APC methylation is universally present in the liver cells and is not a specific marker of liver carcinogenesis and is probably not induced by hepatitis virus infection.
Neg (not) Positive_regulation (induced) of Gene_expression (methylation) of APC in liver associated with familial adenomatous polyposis and hepatitis virus infection
4) Confidence 0.44 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.18 Pain Relevance 0
Liaw and colleagues recently reported that in acute sepsis patients, despite ongoing activation of coagulation, 25% of patients failed to increase their APC levels above 250% (while 75% had levels ranging from approximately 250 to 800%) [28].
Neg (failed) Positive_regulation (increase) of Gene_expression (levels) of APC associated with sepsis
5) Confidence 0.41 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.17 Pain Relevance 0
The obvious limitation is the fact that thrombin formation is also enhanced whenever APC generation is enhanced, and the question remains whether APC or other components of the activated coagulation pathways might be involved.
Positive_regulation (enhanced) of Gene_expression (generation) of APC
6) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.07 Pain Relevance 0.17
Animals were randomly assigned to one of the four following groups: rabbits in the control (CTRL) group (n = 6) received normal saline; those in the LPS group (n = 6) received LPS alone; those in the LPS+aPC group (n = 6) received aPC (2 mg/kg) as a single bolus injection 1 hour after the LPS injection; and 4 rabbits received aPC alone 1 hour after saline injection in the same condition.
Positive_regulation (group) of Gene_expression (received) of aPC
7) Confidence 0.34 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.20 Pain Relevance 0
No death was observed in CTRL and aPC groups.
Positive_regulation (observed) of Gene_expression (groups) of aPC associated with death
8) Confidence 0.34 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.40 Pain Relevance 0.04
gene expression might be attributed to deregulation in the APC/?
Positive_regulation (attributed) of Gene_expression (/) of APC
9) Confidence 0.31 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.71 Pain Relevance 0.03
CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.


Positive_regulation (overexpression) of Gene_expression (overexpression) of APC in colon
10) Confidence 0.22 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12458338 Disease Relevance 0 Pain Relevance 0
Furthermore, APC expression was significantly increased by sulindac at both the early and late stages ( P<0.01).
Positive_regulation (increased) of Gene_expression (expression) of APC
11) Confidence 0.22 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12458338 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our data thus indicate that NS-398 causes an increase in APC expression and a decrease in c-myc expression.


Positive_regulation (increase) of Gene_expression (expression) of APC
12) Confidence 0.20 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
Furthermore, the APC expression level in the group of rats treated with both AOM and NS-398 was significantly greater than that in the group of rats treated with AOM alone; this result for APC gene expression was reconfirmed by the immunohistochemical staining of APC protein.
Positive_regulation (result) of Gene_expression (expression) of APC
13) Confidence 0.16 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our data thus indicate that NS-398 causes an increase in APC expression and a decrease in c-myc expression.


Positive_regulation (causes) of Gene_expression (expression) of APC
14) Confidence 0.14 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
T cell-mediated effects on monocytes included enhanced survival; production of inflammatory cytokines and chemokines; and the development of DC-like characteristics, as evidenced by morphologic features, expression of APC markers, uptake and processing of antigens, and induction of antigen-specific ??
Positive_regulation (induction) of Gene_expression (expression) of APC in T cell associated with chemokine, inflammation and cytokine
15) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.45 Pain Relevance 0.26
Finally, protein expression levels for APC markers on ??
Positive_regulation (levels) of Gene_expression (expression) of APC
16) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0
Most cases of APC resistance are caused by Factor V Leiden mutation.
Positive_regulation (caused) of Gene_expression (resistance) of APC
17) Confidence 0.06 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989116 Disease Relevance 1.63 Pain Relevance 0.29
The treatment of cells with 4 x 10(-4) M indomethacin caused strong inhibition of cell growth (about 70%), enhanced expression of APC, decreased expression of beta-catenin and induced expression of E-cadherin proteins.
Positive_regulation (enhanced) of Gene_expression (expression) of APC
18) Confidence 0.05 Published 2006 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15963497 Disease Relevance 0.76 Pain Relevance 0.20
Concerning plasma fibrinogen levels, a significant increase was observed in the PNP group compared with control animals (p < 0.05), whereas a significant decrease was observed in the APC and the A-PNP groups compared with controls (p < 0.05) (Table 4).
Positive_regulation (observed) of Gene_expression (groups) of APC in plasma associated with pneumonia
19) Confidence 0.05 Published 2006 Journal Respir Res Section Body Doc Link PMC1435891 Disease Relevance 1.19 Pain Relevance 0.06
At a concentration of 4 x 10(-4) M indomethacin there was increased expression of APC gene (10.9-fold induction; DeltaDeltaCt = 3.43) and E-cadherin gene (3.5-fold induction; DeltaDeltaCt = 1.79).
Positive_regulation (increased) of Gene_expression (expression) of APC
20) Confidence 0.04 Published 2006 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15963497 Disease Relevance 0.62 Pain Relevance 0.06

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