INT102107

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 29.48
Pain Relevance 7.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
thymus 6
bladder 4
spleen 4
enterocytes 2
ventricles 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 24 100.00 Very High Very High Very High
Ultiva 18 99.98 Very High Very High Very High
ischemia 124 99.46 Very High Very High Very High
Hippocampus 5 99.38 Very High Very High Very High
Clonidine 3 98.86 Very High Very High Very High
fluoxetine 2 98.28 Very High Very High Very High
amygdala 7 98.08 Very High Very High Very High
Inflammation 71 97.76 Very High Very High Very High
Infliximab 35 97.16 Very High Very High Very High
Etanercept 31 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 629 100.00 Very High Very High Very High
Arrhythmia Under Development 11 100.00 Very High Very High Very High
Heart Rate Under Development 9 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 9 100.00 Very High Very High Very High
Acute Renal Failure 1 99.90 Very High Very High Very High
Obstructive Jaundice 240 99.78 Very High Very High Very High
Injury 129 99.70 Very High Very High Very High
Hypoxia 68 99.62 Very High Very High Very High
Cv Unclassified Under Development 111 99.46 Very High Very High Very High
Pancreatitis 260 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Negative_regulation (inhibited) of Gene_expression (expression) of bax associated with cancer, apoptosis and death
1) Confidence 0.57 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.67 Pain Relevance 0
Infarct size, bax expression, number of ventricular ectopic beats (VEB), duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) were significantly decreased in ischemic preconditioning and 3-NP pretreatment groups, whereas bcl-2 values were not markedly changed in these groups during occlusion period.
Negative_regulation (decreased) of Gene_expression (expression) of bax associated with heart rate under development, arrhythmias 2 under development and arrhythmia under development
2) Confidence 0.57 Published 2008 Journal Life Sci. Section Abstract Doc Link 18387637 Disease Relevance 1.24 Pain Relevance 0.20
Remifentanil reduced expression of pro-apoptotic protein, Bax and cytochrome c.
Negative_regulation (reduced) of Gene_expression (expression) of Bax associated with ultiva and apoptosis
3) Confidence 0.47 Published 2010 Journal Physiol Res Section Abstract Doc Link 19681651 Disease Relevance 0.61 Pain Relevance 0.89
Fluoxetine did not influence Bcl-xl expression in the hippocampus, but it was the only ADT that decreased Bax expression in this region.
Negative_regulation (decreased) of Gene_expression (expression) of Bax in hippocampus associated with hippocampus and fluoxetine
4) Confidence 0.47 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.90 Pain Relevance 0.65
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Negative_regulation (lost) of Gene_expression (expression) of bax associated with ischemia
5) Confidence 0.41 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.56 Pain Relevance 0.15
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Negative_regulation (inhibitor) of Gene_expression (expression) of bax associated with cancer, apoptosis and death
6) Confidence 0.41 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.67 Pain Relevance 0
(fig. 3 I,J) prevented the expression of bax in the ileal enterocytes.
Negative_regulation (prevented) of Gene_expression (expression) of bax in enterocytes
7) Confidence 0.41 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.85 Pain Relevance 0.45
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Negative_regulation (overall) of Gene_expression (expression) of bax associated with ischemia
8) Confidence 0.41 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.60 Pain Relevance 0.15
Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3.
Negative_regulation (reveal) of Gene_expression (expression) of Bax
9) Confidence 0.40 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.67
Administration of higenamine (bolus, i.p) 1 h prior to I/R-injury significantly decreased the release of cytochrome c, caspase-3 activity, and Bax expression but up-regulated the expression of Bcl-2, HO-1, and HO enzyme activity in the left ventricles, which were inhibited by ZnPP IX, an enzyme inhibitor of HO-1.
Negative_regulation (decreased) of Gene_expression (expression) of Bax in ventricles associated with injury
10) Confidence 0.40 Published 2006 Journal Apoptosis Section Abstract Doc Link 16703264 Disease Relevance 0.89 Pain Relevance 0.16
Remifentanil preconditioning increased expression of ERK1/2 and anti-apoptotic protein Bcl-2 and decreased expression of pro-apoptotic proteins, Bax and cytochrome c, compared to ischemia-reperfusion only in wild-type rats.
Negative_regulation (decreased) of Gene_expression (expression) of Bax associated with ischemia, ultiva and apoptosis
11) Confidence 0.39 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19944681 Disease Relevance 2.01 Pain Relevance 1.16
To sum up, Salvia miltiorrhizae injection can exert protective effects on the spleen and thymus of SAP rats and the spleen of OJ rats through reducing the contents of endotoxin and PLA2 in blood, improving the pathological damage present in the spleen and thymus of SAP rats and the spleen of OJ rats, and inhibiting the expression of Bax protein in the spleen of OJ rats and the apoptosis.
Negative_regulation (inhibiting) of Gene_expression (expression) of Bax protein in spleen associated with pancreatitis, apoptosis and obstructive jaundice
12) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.51 Pain Relevance 0.05
However, statistical results showed that the strength of Salvia miltiorrhizae was insufficient in downregulating the expression of Bax protein and inducing apoptosis in the spleen and thymus of SAP and OJ rats, and no statistically significant difference was observed.
Negative_regulation (downregulating) of Gene_expression (expression) of Bax protein in thymus associated with pancreatitis, apoptosis and obstructive jaundice
13) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.48 Pain Relevance 0
After treatment with Salvia miltiorrhizae injection, the expression of Bax protein in the spleen and thymus was, to varying degrees, downregulated, the apoptosis index decreased, and the pathological damage was improved in SAP and OJ rats.
Negative_regulation (downregulated) of Gene_expression (expression) of Bax protein in thymus associated with pancreatitis, apoptosis and obstructive jaundice
14) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.33 Pain Relevance 0
It also reversed the potassium cyanide-induced increased expression of Bax and decreased expression of Bcl-2 to control levels.
Negative_regulation (reversed) of Gene_expression (expression) of Bax
15) Confidence 0.38 Published 2006 Journal Neuroscience Section Abstract Doc Link 16464535 Disease Relevance 0.81 Pain Relevance 0.05
No significant differences occurred in Caspase-3, Bax, and Bcl-2 expression between groups, but cellular changes in cortical areas were significantly correlated with protein expression patterns.
Negative_regulation (occurred) of Gene_expression (expression) of Bax
16) Confidence 0.32 Published 2008 Journal Behav Brain Funct Section Abstract Doc Link PMC2527299 Disease Relevance 0.56 Pain Relevance 0.37
The G-CSF also increased the expression of pSTAT3, Bcl-2, and cIAP2 proteins as well as Bcl-2 mRNA, but inhibited Bax protein expression in the brain.
Negative_regulation (inhibited) of Gene_expression (expression) of Bax in brain
17) Confidence 0.31 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.25 Pain Relevance 0.16
The expression of Bcl-2 and Bax, and the ratio of Bcl-2/Bax recovered to the control level at 3 days and 2 weeks after bladder emptying.
Negative_regulation (recovered) of Gene_expression (expression) of Bax in bladder
18) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.16 Pain Relevance 0
BOO plus subsequent emptying for 30, 60, 120 min showed significant decrease in MnSOD and Bcl-2 expression, and significant increase in caspase 3, Bax expression, and amounts of PAR.
Negative_regulation (amounts) of Gene_expression (expression) of Bax
19) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2967004 Disease Relevance 0.66 Pain Relevance 0.03
When compared to the control group, the I/R group showed significant decrease in Bcl-2 expression and significant increase in the Bax expression at 30 min, 60 min, and 120 min after bladder emptying.
Negative_regulation (decrease) of Gene_expression (expression) of Bax in bladder
20) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.06 Pain Relevance 0

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