INT102122

Context Info Confidence 0.29 First Reported 2002 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 5.83 Pain Relevance 4.94

extracellular space (Calca) aging (Calca) extracellular region (Calca) nucleus (Calca) intracellular (Calca) cytoplasm (Calca)

Anatomy Link Frequency sciatic nerve 2 soma 2 dorsal horn 2 IB4 1 DRG 1 Calca (Rattus norvegicus) RT1-M4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 26 100.00 Dorsal horn 6 98.92 Spinal cord 10 98.60 Nerve growth factor 12 97.36 Sciatic nerve 6 97.24 substance P 6 96.72 dorsal root ganglion 29 96.30 allodynia 4 94.24 peripheral neuropathy 2 93.48 primary afferent fibers 2 83.44

Disease Link Frequency Relevance Heat Hypersensitivity 2 98.64 Nervous System Injury 10 97.38 Ganglion Cysts 32 96.30 Nociception 15 96.22 Neuropathic Pain 6 94.24 Peripheral Neuropathy 2 93.48 Injury 4 92.28 Shock 4 91.48 Pain 5 77.40 Increased Venous Pressure Under Development 8 72.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunocytochemical detection of calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4) binding was used to visualize the dorsal horn distribution of the boutons from the peptidergic and non-peptidergic fibers respectively.

CGRP Binding (binding) of IB4 in dorsal horn associated with dorsal horn and calcitonin gene-related peptide

1) Confidence 0.29 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.90 Pain Relevance 0.80

Immunocytochemical detection of calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4) binding was used to visualize the dorsal horn distribution of the boutons from the peptidergic and non-peptidergic fibers respectively.

calcitonin gene-related peptide Binding (binding) of IB4 in dorsal horn associated with dorsal horn and calcitonin gene-related peptide

2) Confidence 0.22 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.91 Pain Relevance 0.80

Here we provide the first direct comparison of rat pulmonary spinal and vagal pulmonary afferent neurons with respect to structural (soma size) and two neurochemical characteristics (binding of lectin IB4, immunoreactivity to calcitonin gene-related peptide=CGRP).

CGRP Binding (binding) of IB4 in soma associated with calcitonin gene-related peptide

3) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16309834 Disease Relevance 0.71 Pain Relevance 0.48

Here we provide the first direct comparison of rat pulmonary spinal and vagal pulmonary afferent neurons with respect to structural (soma size) and two neurochemical characteristics (binding of lectin IB4, immunoreactivity to calcitonin gene-related peptide=CGRP).

calcitonin Binding (binding) of IB4 in soma associated with calcitonin gene-related peptide

4) Confidence 0.04 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16309834 Disease Relevance 0.70 Pain Relevance 0.48

A proportion of the CB1 receptor-like immunopositive neurones was immunostained for CGRP (31.7+/-5%) and IB4 (48.2%+/-7.5), with a minimal (1%) co-expression of CGRP and IB4 binding.

CGRP Binding (binding) of IB4 in IB4 associated with calcitonin gene-related peptide

5) Confidence 0.01 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934481 Disease Relevance 0.36 Pain Relevance 0.48

Following sciatic nerve injury in adult rats and treatment with BRX-220, the following features of the sensory system were studied: (a) expression of calcitonin gene-related peptide (CGRP); (b) binding of isolectin B4 (IB4) in dorsal root ganglia (DRG) and spinal cord; (c) stimulation-evoked release of substance P (SP) in an in vitro spinal cord preparation and (d) nociceptive responses of partially denervated rats.

CGRP Binding (binding) of IB4 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve, substance p, spinal cord and calcitonin gene-related peptide

6) Confidence 0.01 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.62 Pain Relevance 0.49

Following sciatic nerve injury in adult rats and treatment with BRX-220, the following features of the sensory system were studied: (a) expression of calcitonin gene-related peptide (CGRP); (b) binding of isolectin B4 (IB4) in dorsal root ganglia (DRG) and spinal cord; (c) stimulation-evoked release of substance P (SP) in an in vitro spinal cord preparation and (d) nociceptive responses of partially denervated rats.

gene-related peptide Binding (binding) of IB4 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve, substance p, spinal cord and calcitonin gene-related peptide

7) Confidence 0.01 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.62 Pain Relevance 0.49

Small nociceptive DRG neurons are classified into nerve growth factor (NGF)-dependent neurons and glial cell line-derived neurotrophic factor (GDNF)-dependent neurons and they can be distinguished by their reactivity for CGRP and IB4, respectively.

CGRP Binding (reactivity) of IB4 in DRG associated with nociception, dorsal root ganglion, nerve growth factor and calcitonin gene-related peptide

8) Confidence 0.01 Published 2004 Journal Life Sci. Section Abstract Doc Link 15041445 Disease Relevance 1.02 Pain Relevance 0.92

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