INT102146

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.48
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neurons 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 99.64 Very High Very High Very High
Ultiva 9 96.20 Very High Very High Very High
fibrosis 14 95.44 Very High Very High Very High
antagonist 9 88.84 High High
opiate 2 88.04 High High
agonist 14 84.92 Quite High
ischemia 3 77.16 Quite High
anesthesia 4 75.52 Quite High
Opioid 1 74.96 Quite High
nMDA receptor 6 61.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 77 100.00 Very High Very High Very High
Myocardial Infarction 80 99.78 Very High Very High Very High
Death 14 97.04 Very High Very High Very High
Cardiovascular Disorder Under Development 2 95.44 Very High Very High Very High
Coronary Heart Disease 10 93.60 High High
Diabetes Mellitus 55 90.00 High High
Hypertrophy 14 81.76 Quite High
Fibrosis 12 78.88 Quite High
Cv Unclassified Under Development 3 77.16 Quite High
Stress 8 68.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myocardial infarct size, the phosphorylation of ERK1/2, Bcl2, Bax and cytochrome c and the expression of genes influencing Ca2+ homeostasis were assessed.
Phosphorylation (phosphorylation) of Bax associated with myocardial infarction
1) Confidence 0.66 Published 2010 Journal Physiol Res Section Abstract Doc Link 19681651 Disease Relevance 0.63 Pain Relevance 0.93
Western blotting was used to study Caspase-3, Bax, Sirt1, acetylation of p53 and phosphorylation of p38, Akt and FOXO3a.
Phosphorylation (phosphorylation) of Bax
2) Confidence 0.42 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.50 Pain Relevance 0.09
In granule neurons, the protein Bax has been described to be phosphorylated by GSK3, and this could be one possible target for P2X7 receptors [15].
Phosphorylation (phosphorylated) of Bax in neurons
3) Confidence 0.25 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.19 Pain Relevance 0.03
Among different potential GSK3 targets, Bax, a protein of the intrinsic apoptotic cascade that is involved in mitochondrial pore formation, has been reported to become phosphorylated and translocated to mitochondria upon GSK3 activation in granule neurons [15].
Phosphorylation (phosphorylated) of Bax in neurons associated with apoptosis
4) Confidence 0.25 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.75 Pain Relevance 0.07
Anti-TGF-beta Ab also attenuated morphine-induced p53 as well as inducible NO synthase expression; in contrast, N(G)-nitro-L-arginine methyl ester, an inhibitor of NO synthase, inhibited morphine-induced P38 MAPK phosphorylation and Bax expression.
Phosphorylation (phosphorylation) of Bax associated with morphine
5) Confidence 0.07 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11937560 Disease Relevance 0.42 Pain Relevance 1.23

General Comments

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