INT102253

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 75
Total Number 77
Disease Relevance 24.23
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brain 4
neuronal 2
plaques 2
thalamus 2
upper 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 290 100.00 Very High Very High Very High
Hippocampus 165 99.28 Very High Very High Very High
ischemia 132 95.24 Very High Very High Very High
agonist 59 89.60 High High
Lasting pain 10 87.04 High High
Glutamate 61 81.68 Quite High
Central nervous system 60 64.96 Quite High
GABAergic 24 61.36 Quite High
Neurotransmitter 10 60.72 Quite High
anesthesia 74 59.84 Quite High
Disease Link Frequency Relevance Heat
Stress Incontinence 315 99.92 Very High Very High Very High
Neuroblastoma 52 99.84 Very High Very High Very High
Targeted Disruption 274 99.64 Very High Very High Very High
Death 218 99.16 Very High Very High Very High
Neurologic Manifestations 18 98.92 Very High Very High Very High
Disease 820 98.24 Very High Very High Very High
Sprains And Strains 520 98.12 Very High Very High Very High
Scrapie 730 97.28 Very High Very High Very High
Prion Diseases 303 97.14 Very High Very High Very High
Amyloid Plaque 26 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease of PrPC mRNA levels in the necrotic area is readily explained by the large number of dying cells in this area.
Negative_regulation (decrease) of PrPC mRNA
1) Confidence 0.59 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.36 Pain Relevance 0.08
In contrast, PrPC mRNA levels were significantly decreased in the necrotic area (N) (P < 0.05), which may be associated with the massive cell death in this area.


Negative_regulation (decreased) of PrPC mRNA associated with death
2) Confidence 0.59 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.44 Pain Relevance 0.20
The observation that cholesterol depletion reduces PrPSc levels has highlighted the importance of the lipid environment for scrapie production [50].
Negative_regulation (reduces) of PrPSc associated with scrapie
3) Confidence 0.58 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.18 Pain Relevance 0
Indeed, when we blocked PrP exit from EEs the levels of PrPSc were drastically reduced and an accumulation of PrPC in EEs was observed (Figures 2A, 2C, 5A, 5B, S8B, S8C and S8D).
Negative_regulation (reduced) of PrPSc
4) Confidence 0.58 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
As PrP level remained unchanged, we conclude that GA does not act by decreasing the steady state level of PrP.


Negative_regulation (decreasing) of PrP
5) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
The quinacrine concentrations needed for half-maximal depletion of PrPSc (EC50) in cell culture were reported to be ?
Negative_regulation (depletion) of PrPSc
6) Confidence 0.54 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.08 Pain Relevance 0.03
Our data show a robust enhancement of synaptic NMDA currents in PrP-null mice, which could be mimicked upon siRNA depletion of PrPC and rescued by overexpression of exogenous Prnp cDNA.
Negative_regulation (depletion) of PrPC
7) Confidence 0.51 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.34 Pain Relevance 0.10
In contrast, no reduction in PrPSc was observed when Rab22a was overexpressed in ScN2a cells, where Rab22a does not control this pathway (data not shown).
Negative_regulation (reduction) of PrPSc
8) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Indeed, we observed a decrease in PrPSc when we overexpressed Rab22a in both ScGT1 (Figure 5) and ScCAD (Figure S8) cells, where Rab22a has a clear effect in inhibiting transport from EEs to ERC.
Negative_regulation (decrease) of PrPSc
9) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
This partial decrease in PrPSc levels corresponded to the transfection efficiency, which was approximately 50% (data not shown).
Negative_regulation (decrease) of PrPSc
10) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
As expected, when endogenous Rab22a was depleted from ScGT1 cells a similar decrease in PrPSc levels was obtained (Figure S7B).
Negative_regulation (decrease) of PrPSc
11) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.06 Pain Relevance 0
Therefore, under these conditions the reduction in PrPSc was likely due to inhibition of PrPSc production rather than its increased degradation.
Negative_regulation (reduction) of PrPSc
12) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
To rule out this hypothesis we monitored the distribution of PrPSc and Alexa-546 dextran in ScGT1 cells expressing GFP-Rab22a three days post-transfection, when the reduction of PrPSc was not complete and when we could still detect PrPSc in the transfected cells.
Negative_regulation (reduction) of PrPSc
13) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Pharmacological reduction of PrPSc is clinically meaningful only if it prevents neurodegeneration.
Negative_regulation (reduction) of PrPSc
14) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.90 Pain Relevance 0.16
In the brains of prion-inoculated MDR0/0 mice, PrPSc levels diminished upon the initiation of quinacrine treatment, remained low for several days, but gradually increased despite the continuous presence of the drug.
Negative_regulation (diminished) of PrPSc in brains
15) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.08 Pain Relevance 0
site, which inactivates the biological active form of PrP cleaved at the ?
Negative_regulation (inactivates) of PrP
16) Confidence 0.43 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.14 Pain Relevance 0
Experiments in cerebellar granule cells (5) have shown a loss of neuroprotective activity of PrPC by a deletion of all five N-terminal octarepeats (PrP?
Negative_regulation (loss) of PrPC in cerebellar granule cells
17) Confidence 0.43 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.43 Pain Relevance 0.03
In accordance with our data, McMahon et al (22) found a decrease of PrPC FL and an increase of amino-terminally fragmented PrPC in cells under oxidative stress.
Negative_regulation (decrease) of PrPC associated with stress
18) Confidence 0.43 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.15 Pain Relevance 0
We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrP(c)), those overexpressing the prion protein, and two groups of genetically and age-matched controls.
Negative_regulation (deficient) of PrP
19) Confidence 0.43 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11950500 Disease Relevance 0.22 Pain Relevance 0.06
We further show that AchR-expressing neuronal cells specifically targeted by RVG-9r LSPCs also express PrPC, which was suppressed 70% by PrP siRNA LSPCs 48 hours after treatment.
Negative_regulation (suppressed) of PrPC in neuronal
20) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.05 Pain Relevance 0

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