INT102350

Context Info Confidence 0.32 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.67

extracellular space (Il6) transport (P2rx1) extracellular region (Il6) plasma membrane (P2rx1) protein complex (P2rx1)

P2rx1 (Mus musculus) Il6 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 5 100.00 adenocard 9 95.80 Neuropeptide 1 89.80 Opioid 1 89.08 antagonist 2 52.24

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The P2X(1) agonist beta,gamma-methylene ATP inhibited IL-6 secretion at 10(-5) M, whereas the P2Y(1) agonist 2-methylthio ATP increased IL-6 secretion at 10(-6) to 10(-8) M.

P2X Negative_regulation (inhibited) of Localization (secretion) of IL-6 associated with agonist

1) Confidence 0.32 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.67

General Comments

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