INT102638

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 9.92
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
muscle 4
SkM 1
intervertebral disc 1
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 3 100.00 Very High Very High Very High
Pain 158 99.84 Very High Very High Very High
Lasting pain 93 99.70 Very High Very High Very High
carbamazepine 36 95.36 Very High Very High Very High
backache 12 89.60 High High
Osteoarthritis 105 87.20 High High
Multiple sclerosis 38 85.68 High High
Fibrositis 11 77.48 Quite High
Lamotrigine 2 70.28 Quite High
cINOD 8 50.40 Quite High
Disease Link Frequency Relevance Heat
Pain 229 99.84 Very High Very High Very High
Reprotox - General 1 13 99.84 Very High Very High Very High
Osteogenic Sarcomas 79 99.74 Very High Very High Very High
Sunburn 32 99.60 Very High Very High Very High
Rickets 93 99.04 Very High Very High Very High
Bone Cancer 27 98.88 Very High Very High Very High
Disease 175 98.72 Very High Very High Very High
Osteoporosis 175 97.52 Very High Very High Very High
Epilepsy 62 97.44 Very High Very High Very High
Mycobacterial Infection 30 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other polymorphic genes, such as the one encoding ERa, have been shown to modulate the effect of the VDR gene in the determination of BMD, confirming the existence of gene?
Regulation (effect) of VDR
1) Confidence 0.44 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.05 Pain Relevance 0
Studies of the gene for vitamin D receptor
Regulation (Studies) of vitamin D receptor
2) Confidence 0.44 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.70 Pain Relevance 0.19
Most recently, VDR polymorphisms have been described to affect muscle function.
Regulation (affect) of VDR in muscle
3) Confidence 0.42 Published 2002 Journal Osteoporos Int Section Abstract Doc Link 11991436 Disease Relevance 0.18 Pain Relevance 0
When we checked the response to vitamin D and calcium therapy, we found that out of 20 patients placed on calcium and/or vitamin D, 13 patients showed significant clinical improvement.
Regulation (response) of vitamin D
4) Confidence 0.38 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.84 Pain Relevance 0.18
While osteomalacia and rickets have been studied extensively, there is little information on vitamin D deficiency without obvious bone disease.
Neg (little) Regulation (information) of vitamin D associated with rickets and bone cancer
5) Confidence 0.38 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.73 Pain Relevance 0
Furthermore, indirect evidence that vitamin D levels are important in pain is provided by the association of latitude and season of the year with pain [5–7].
Regulation (important) of vitamin D associated with pain
6) Confidence 0.29 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778183 Disease Relevance 0.60 Pain Relevance 0.61
Thus, the anti-OS activity of VDR is dependent on many other nuclear proteins, including BRCA1 and RXRs.

11.

Regulation (dependent) of VDR associated with osteogenic sarcomas
7) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.82 Pain Relevance 0
The importance of vitamin D in skeletal muscle (SkM) function has been demonstrated by the presence of the vitamin D receptor (VDR) in both the nucleus and plasma membrane of human SkM fibers [3] and by defective muscle development and function in VDR knockout mice [4].
Regulation (importance) of vitamin D in SkM associated with targeted disruption
8) Confidence 0.24 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3010688 Disease Relevance 0.27 Pain Relevance 0.08
As shown in Figure 7B, expression of neither native DREAM nor the EF-LCDmut affected significantly the activity of GAL-VDR or GAL-RAR in the absence of ligand.
Regulation (affected) of GAL-VDR
9) Confidence 0.23 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
Thus those factors have great effects on vitamin D production [28,29].
Regulation (effects) of vitamin D
10) Confidence 0.22 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.05 Pain Relevance 0
Furthermore parathormone has a muscle action that is independent of vitamin D [22].
Neg (independent) Regulation (independent) of vitamin D in muscle
11) Confidence 0.22 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2959005 Disease Relevance 0.16 Pain Relevance 0
Like observation studies, intervention studies have demonstrated discordant results concerning the effects of vitamin D supplementation on muscle function [21,45].
Regulation (effects) of vitamin D in muscle
12) Confidence 0.22 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2959005 Disease Relevance 0.27 Pain Relevance 0
Furthermore, Stein et al. [65] have suggested that the muscle effect of vitamin D insufficiency could be due to parathormone and not to a direct action of vitamin D on muscle.
Regulation (effect) of vitamin D in muscle
13) Confidence 0.22 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2959005 Disease Relevance 0.07 Pain Relevance 0
Overall, we found the expected dependence of 25-OH vitamin D level on latitude of study location (sunlight) and lower levels of 25-OH vitamin D in immigrant/ethnic minority populations with chronic pain compared with patients from the general population with chronic pain.

4.

Regulation (dependence) of vitamin D associated with addiction and lasting pain
14) Confidence 0.18 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778183 Disease Relevance 0.82 Pain Relevance 0.75
For inclusion in this review studies needed to be conducted in ethnic minority or immigrant subjects with chronic pain, to give mean values for 25-OH vitamin D levels in these populations, and/or to investigate pain outcomes after vitamin D supplementation.
Regulation (values) of vitamin D associated with pain and lasting pain
15) Confidence 0.18 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778183 Disease Relevance 0.42 Pain Relevance 0.42
Since the intervertebral disc is also rich in proteoglycan, these findings suggest that the vitamin-D receptor may be directly involved in the pathophysiology of the degenerated intervertebral disc.
Spec (may) Regulation (involved) of vitamin-D receptor in intervertebral disc
16) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.22 Pain Relevance 0
The efficacies of vitamin D, as demonstrated by the meta-analyses reported in this period, are largely unconvincing apart from in relation to falls and fractures in the elderly.
Regulation (efficacies) of vitamin D
17) Confidence 0.14 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 1.10 Pain Relevance 0.04
In addition to vitamin D-related phosphocalcic regulation, the vitamin D-related fall rate reduction induces a fracture rate reduction.
Regulation (regulation) of vitamin D
18) Confidence 0.13 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2959005 Disease Relevance 0.08 Pain Relevance 0
Emerging evidence shows that these PXR activators can increase the expression of the CYP24, a VDR target gene in cultured cells and in vivo in mice.
Regulation (target) of VDR
19) Confidence 0.12 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.53 Pain Relevance 0.07
This rise in PTH levels likely represents a secondary response to low vitamin D levels.
Regulation (response) of vitamin D
20) Confidence 0.10 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

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