INT102680

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 49
Total Number 53
Disease Relevance 34.68
Pain Relevance 15.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
lung 4
fibroblasts 3
ECM 3
tendons 3
cartilage 3
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
Inflammation 480 99.90 Very High Very High Very High
Osteoarthritis 487 99.84 Very High Very High Very High
metalloproteinase 289 99.80 Very High Very High Very High
rheumatoid arthritis 100 99.32 Very High Very High Very High
Snapping jaw 22 99.00 Very High Very High Very High
Gabapentin 8 98.74 Very High Very High Very High
Inflammatory mediators 76 98.70 Very High Very High Very High
corticosteroid 61 98.56 Very High Very High Very High
cytokine 88 97.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 230 100.00 Very High Very High Very High
INFLAMMATION 644 99.90 Very High Very High Very High
Osteoarthritis 316 99.84 Very High Very High Very High
Knee Osteoarthritis 134 99.84 Very High Very High Very High
Stress 148 99.76 Very High Very High Very High
Fibrosis 81 99.74 Very High Very High Very High
Necrosis 48 99.34 Very High Very High Very High
Vascular Disease 10 99.34 Very High Very High Very High
Rheumatoid Arthritis 100 99.32 Very High Very High Very High
Apoptosis 61 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degradation kinetics of a model peptide, leucine enkephalin (Tyr-Gly-Gly-Phe-Leu, Leu-Enk), was determined in four nasal cell culture systems: immersion, air-liquid interface, sequential monolayer-suspension, floating collagen.
Spec (determined) Protein_catabolism (degradation) of collagen in nasal associated with enkephalin
1) Confidence 0.69 Published 2002 Journal Int J Pharm Section Abstract Doc Link 11996828 Disease Relevance 0 Pain Relevance 0.10
Studies by Antoniou et al have pointed out that it is very difficult to distinguish between synthesis of new matrix, degradation products, and resident matrix collagen [12].
Protein_catabolism (degradation) of collagen
2) Confidence 0.65 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.24 Pain Relevance 0.09
Collagen degradation, measured as carboxyterminal telopeptide region of type I collagen (ICTP), was not affected by training neither in the injured nor in the healthy tendons.
Protein_catabolism (degradation) of Collagen in tendons
3) Confidence 0.64 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.40 Pain Relevance 0.13
Hydroxyprolme appears in urine after degradation of collagen (collagenosis), which may originate from various tissues [25].
Protein_catabolism (degradation) of collagen in urine
4) Confidence 0.63 Published 2008 Journal Virol J Section Body Doc Link PMC2291039 Disease Relevance 0.62 Pain Relevance 0.04
Degradation of bone collagen releases free 4-hydroxyproline and peptides containing 4-hydroxyproline into the plasma.
Protein_catabolism (Degradation) of collagen in plasma
5) Confidence 0.63 Published 2008 Journal Virol J Section Body Doc Link PMC2291039 Disease Relevance 0.60 Pain Relevance 0.04
Each group was compared with normal lung tissue with respect to tissue collagen and collagen degradation product content (hydroxyproline assay), gelatinolytic activity (zymography) and the expression of matrix metalloproteinases, MMP-2 and MMP-9 (Western immunoblot).
Protein_catabolism (degradation) of collagen in lung associated with metalloproteinase
6) Confidence 0.62 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.62 Pain Relevance 0.37
The mechanism of their action on collagen biosynthesis involves inactivation of prolidase, the enzyme that recovers proline from collagen degradation products for collagen re-synthesis.
Protein_catabolism (degradation) of collagen
7) Confidence 0.55 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.09 Pain Relevance 0.26
Although extracellular collagenases initiate the breakdown of tissue collagen the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9).
Protein_catabolism (degradation) of collagen
8) Confidence 0.55 Published 2002 Journal Hepatogastroenterology Section Abstract Doc Link 12397770 Disease Relevance 0.33 Pain Relevance 0.12
The lung adenocarcinoma G1 had a similar collagen content as normal lung tissue but increased amounts of collagen degradation products and free hydroxyproline.
Protein_catabolism (degradation) of collagen in lung associated with adenocarcinoma
9) Confidence 0.47 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.71 Pain Relevance 0.36
In contrast, adenocarcinoma G3 had an increased tissue collagen content (by about 60%), decreased percentage of collagen degradation products and similar gelatinolytic activity, compared to normal lung.
Protein_catabolism (degradation) of collagen in lung associated with adenocarcinoma
10) Confidence 0.47 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.83 Pain Relevance 0.28
In adenocarcinoma G2, the free hydroxyproline content and gelatinolytic activity were increased, while the collagen and collagen degradation product contents were not markedly altered, compared to control.
Protein_catabolism (degradation) of collagen associated with adenocarcinoma
11) Confidence 0.47 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.83 Pain Relevance 0.33
In adenocarcinoma G2, the free hydroxyproline content and gelatinolytic activity were increased, while the collagen and collagen degradation product contents were not markedly altered, compared to control.
Protein_catabolism (degradation) of collagen associated with adenocarcinoma
12) Confidence 0.41 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.82 Pain Relevance 0.33
Each group was compared with normal lung tissue with respect to tissue collagen and collagen degradation product content (hydroxyproline assay), gelatinolytic activity (zymography) and the expression of matrix metalloproteinases, MMP-2 and MMP-9 (Western immunoblot).
Protein_catabolism (degradation) of collagen in lung associated with metalloproteinase
13) Confidence 0.41 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.62 Pain Relevance 0.37
Nevertheless, the hypothesis that eosinophils are involved in enzymatic degradation and depolymerization of the pubic symphysis collagen needs to be tested in future experiments.
Protein_catabolism (degradation) of collagen in eosinophils
14) Confidence 0.38 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.10 Pain Relevance 0
Gabapentin (120 and 240 microM) also concentration-dependently inhibited collagen (1 microg mL(-1))-induced phosphoinositide breakdown, intracellular Ca(2+) mobilization, thromboxane A(2) formation, and p38 MAPK phosphorylation in human platelets.
Protein_catabolism (breakdown) of collagen in platelets associated with gabapentin
15) Confidence 0.37 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883897 Disease Relevance 0.08 Pain Relevance 0.75
Novel nonmatrix-metalloproteinase-mediated collagen degradation.
Protein_catabolism (degradation) of collagen associated with metalloproteinase
16) Confidence 0.33 Published 2005 Journal Biochim. Biophys. Acta Section Title Doc Link 15652180 Disease Relevance 0.56 Pain Relevance 0.84
The degradation of wound collagen is controlled by collagenases and other proteolytic enzymes, and the net increase in wound collagen is determined by the balance of these opposing mechanisms.
Protein_catabolism (degradation) of collagen associated with injury
17) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 0.96 Pain Relevance 0.11
The collagen degradation assay showed that these TMJ synovial fibroblasts at passage 3 to 8 were capable of digesting the collagen underneath them on collagen-coated plates.
Protein_catabolism (degradation) of collagen in fibroblasts associated with snapping jaw
18) Confidence 0.29 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15652180 Disease Relevance 0.59 Pain Relevance 0.85
Collagen can be fabricated as a membrane, gel, sponge or foam and is subject to enzymatic degradation.
Protein_catabolism (degradation) of Collagen
19) Confidence 0.28 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Body Doc Link PMC2688024 Disease Relevance 0 Pain Relevance 0
Collagen is indeed a core component of the ECM, and undergoes remodeling that is dependent on both continued collagen synthesis and compensatory collagen degradation.
Protein_catabolism (degradation) of collagen in ECM
20) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 0.96 Pain Relevance 0.11

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