INT10276

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.85
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il1b, Penk) extracellular space (Il1b) aging (Il1b)
Anatomy Link Frequency
astrocytes 6
Il1b (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
adenocard 3 98.40 Very High Very High Very High
Central nervous system 12 96.64 Very High Very High Very High
Glutamate 3 93.76 High High
agonist 3 91.64 High High
Opioid 6 87.28 High High
cytokine 3 85.84 High High
Disease Link Frequency Relevance Heat
Gliosis 3 92.88 High High
Injury 9 91.96 High High
Disease 3 91.56 High High
Stress 6 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-1 beta regulates proenkephalin gene expression in astrocytes cultured from rat cortex.
Interleukin-1 beta Regulation (regulates) of Gene_expression (expression) of proenkephalin in astrocytes associated with enkephalin
1) Confidence 0.61 Published 1992 Journal Glia Section Title Doc Link 1478730 Disease Relevance 0.28 Pain Relevance 0.55
Interleukin-1 beta also regulated a proenkephalin-chloramphenicol acetyltransferase fusion gene transiently transfected into astrocytes, with a dose-response similar to that active in proenkephalin mRNA.
Interleukin-1 beta Regulation (regulated) of Gene_expression (transfected) of proenkephalin in astrocytes
2) Confidence 0.44 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.28 Pain Relevance 0.47
Interleukin-1 beta also regulated a proenkephalin-chloramphenicol acetyltransferase fusion gene transiently transfected into astrocytes, with a dose-response similar to that active in proenkephalin mRNA.
Interleukin-1 beta Regulation (regulated) of Gene_expression (transfected) of proenkephalin in astrocytes
3) Confidence 0.44 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.29 Pain Relevance 0.48

General Comments

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