INT102992

Context Info Confidence 0.60 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.59 Pain Relevance 0.29

cell differentiation (SRD5A1) small molecule metabolic process (SRD5A1) endoplasmic reticulum (SRD5A1) cytoplasm (SRD5A1)

SRD5A1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 36 100.00 Onset of action 2 41.36 c fibre 1 29.28 Central nervous system 2 25.00 Inflammation 11 5.00 cINOD 7 5.00 Pain 4 5.00 alcohol 3 5.00 cva 3 5.00 agonist 2 5.00

Disease Link Frequency Relevance Heat Overactive Bladder 229 99.84 Benign Prostatic Hypertrophy 248 99.08 Hematuria 11 97.96 Reprotox - General 1 18 97.84 Lower Urinary Tract Symptoms 85 93.28 Pressure Volume 2 Under Development 5 85.96 Dizziness 3 84.96 Gynecomastia 4 54.80 Disease 17 50.00 Stress Incontinence 8 27.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Role of 5-alpha reductase inhibitors in AUR

Regulation (Role) of Negative_regulation (inhibitors) of 5-alpha reductase associated with overactive bladder

1) Confidence 0.60 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.26 Pain Relevance 0

Theoretically, there seem to be several possibilities to improve the current treatment, which is based mainly on alpha1-adrenoceptor (AR) antagonists, 5alpha-reductase inhibitors and phytotherapy.

Regulation (based) of Negative_regulation (inhibitors) of 5alpha-reductase associated with antagonist

2) Confidence 0.44 Published 2002 Journal World J Urol Section Abstract Doc Link 12022712 Disease Relevance 0.54 Pain Relevance 0.24

The role of 5-alpha-reductase inhibitors

Regulation (role) of Negative_regulation (inhibitors) of 5-alpha-reductase

3) Confidence 0.44 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2440415 Disease Relevance 0.81 Pain Relevance 0

Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44 5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Regulation (role) of Negative_regulation (inhibitor) of 5-alpha-reductase associated with benign prostatic hypertrophy, antagonist and hematuria

4) Confidence 0.44 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.99 Pain Relevance 0.05

General Comments

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