INT103130

Context Info Confidence 0.09 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0.39

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8) intracellular (IL8) plasma membrane (DCSTAMP)

DCSTAMP (Homo sapiens) IL8 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 6 97.54

Disease Link Frequency Relevance Heat Skin Cancer 8 99.84 Necrosis 1 88.08 Cancer 1 87.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.

IL-1beta-induced Positive_regulation (induced) of Gene_expression (expression) of IL-8 associated with qutenza and skin cancer

1) Confidence 0.09 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.65 Pain Relevance 0.39

General Comments

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