INT103132

Context Info Confidence 0.03 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.43

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) plasma membrane (DCSTAMP)

DCSTAMP (Homo sapiens) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 6 99.78

Disease Link Frequency Relevance Heat Skin Cancer 8 99.36 Necrosis 1 69.52 Cancer 1 69.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.

Positive_regulation (activation) of IL-1beta-induced Positive_regulation (induced) of AP-1 associated with qutenza and skin cancer

1) Confidence 0.03 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.73 Pain Relevance 0.43

General Comments

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