INT103135

Context Info Confidence 0.09 First Reported 2002 Last Reported 2003 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.86 Pain Relevance 0.80

plasma membrane (DCSTAMP)

DCSTAMP (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 6 99.78 dexamethasone 1 97.36 cINOD 6 93.84 COX-2 inhibitor 1 70.52 COX2 1 25.00

Disease Link Frequency Relevance Heat Skin Cancer 8 99.36 INFLAMMATION 2 75.00 Necrosis 1 69.52 Cancer 1 69.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Treatment with Flur, NS-398, Cig, and 15d-PGJ(2) alone, but not Indo and WY-14643, elevated COX activity; however, neither enhanced IL-1beta-induced COX activity.

Neg (neither) Positive_regulation (induced) of IL-1beta-induced

1) Confidence 0.09 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.14 Pain Relevance 0.37

Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.

Positive_regulation (activation) of IL-1beta-induced associated with qutenza and skin cancer

2) Confidence 0.06 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.73 Pain Relevance 0.43

General Comments

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