INT103285

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Latest revision as of 07:31, 24 September 2012

Context Info
Confidence 0.44
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
stromal cells 2
monocyte 1
neurons 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 99.48 Very High Very High Very High
chemokine 16 97.88 Very High Very High Very High
cytokine 2 97.04 Very High Very High Very High
Nucleus accumbens 1 95.84 Very High Very High Very High
Limbic system 1 94.32 High High
Hippocampus 1 93.12 High High
Thalamus 1 92.08 High High
pain pelvic 2 84.40 Quite High
endometriosis 2 81.92 Quite High
Opioid 1 45.76 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 4 100.00 Very High Very High Very High
INFLAMMATION 8 99.48 Very High Very High Very High
Endometriosis 3 98.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 91 93.64 High High
Reprotox - General 3 2 84.40 Quite High
Disease 6 83.36 Quite High
Cardiovascular Disease 2 80.00 Quite High
Infection 24 67.84 Quite High
Opportunistic Infections 3 23.72 Low Low
Death 2 12.76 Low Low

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of in monocyte Localization (secreted) of CCL5 in neurons associated with chemokine and inflammation
1) Confidence 0.44 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.72
RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometrial and endometriotic stromal cells and circulates in peritoneal fluid.
Regulation (regulated) of Localization (secreted) of RANTES in stromal cells associated with endometriosis
2) Confidence 0.34 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.34 Pain Relevance 0.13
Moreover, some evidence suggests that statins alter the intracellular signals dependent on Rho GTPases [16], the functional activity of LFA-1/ICAM-1 adhesion molecules [17], the expression of the CCR5 coreceptor and the secretion of RANTES [18], and may exert significant modulatory effects on the balance of the cytokine network in human beings [19,20].
Regulation (dependent) of Localization (secretion) of RANTES associated with adhesions and cytokine
3) Confidence 0.06 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.67 Pain Relevance 0.05

[edit] General Comments

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