INT103320

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 44
Total Number 47
Disease Relevance 27.73
Pain Relevance 25.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 12
adipose tissue 12
nerve 6
liver 4
nociceptor 4
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 1140 100.00 Very High Very High Very High
dorsal root ganglion 352 100.00 Very High Very High Very High
calcitonin gene related peptide 70 100.00 Very High Very High Very High
antagonist 270 99.96 Very High Very High Very High
Glutamate 49 99.96 Very High Very High Very High
Inflammatory mediators 41 99.88 Very High Very High Very High
bradykinin 46 99.84 Very High Very High Very High
nociceptor 109 99.60 Very High Very High Very High
anesthesia 19 99.42 Very High Very High Very High
Hyperalgesia 128 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 463 100.00 Very High Very High Very High
INFLAMMATION 380 99.68 Very High Very High Very High
Targeted Disruption 170 99.48 Very High Very High Very High
Hyperalgesia 224 99.30 Very High Very High Very High
Pain 345 98.88 Very High Very High Very High
Obesity 109 98.82 Very High Very High Very High
Cancer 43 98.78 Very High Very High Very High
Increased Venous Pressure Under Development 44 98.04 Very High Very High Very High
Fever 22 98.00 Very High Very High Very High
Injury 42 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent advances in pain biology such as the cloning of the transient receptor potential vanilloid 1 (TRPV1) ion channel, exploration of the molecular mechanisms leading to TRPV1 activation and the production of a TRPV1 mutant mouse have defined its role as an integrator of noxious thermal and chemical stimuli.
Positive_regulation (leading) of Positive_regulation (activation) of TRPV1 associated with pain
1) Confidence 0.70 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 19450765 Disease Relevance 0.91 Pain Relevance 0.48
This effect is TRPV1 specific as it was inhibited by capsazepine and suggested to occur as a result of CGRP and tachykinin release upon TRPV1 activation [86].
Positive_regulation (result) of Positive_regulation (activation) of TRPV1 associated with calcitonin gene related peptide
2) Confidence 0.69 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.65 Pain Relevance 0.59
This region might thus be very important for the activation of TRPV1.
Spec (might) Positive_regulation (important) of Positive_regulation (activation) of TRPV1
3) Confidence 0.69 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.08 Pain Relevance 0.37
The release of these neuropeptides from primary afferent (sensory) nerve endings to various stimuli is considered to be induced by activation of the capsaicin (vanilloid) receptor (VR1).
Positive_regulation (induced) of Positive_regulation (activation) of VR1 in nerve associated with qutenza and neuropeptide
4) Confidence 0.50 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906843 Disease Relevance 0.09 Pain Relevance 0.40
In conclusion, based on the extent of SP and VR1 co-localization in nasal afferent neurons, the present study suggests that, following a peripheral activation of the VR1 receptor on SP afferents, there could be a triggering of SP-mediated phenomena, including those related to inflammation, such as plasma extravasation.
Positive_regulation (triggering) of Positive_regulation (activation) of VR1 in plasma associated with inflammation
5) Confidence 0.50 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906843 Disease Relevance 0.15 Pain Relevance 0.43
CONCLUSION: These results suggest that activation of the TRPV1 receptor by mediators of inflammation induces sensory neuropeptide release, which might exert protective action against fibrosis.
Positive_regulation (induces) of Positive_regulation (activation) of TRPV1 receptor
6) Confidence 0.50 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18163477 Disease Relevance 0 Pain Relevance 0
From these results, we conclude that activation of TRPV1 in the mouse intestine induces a contraction that is mediated by tachykinins most likely released from afferent nerves.
Positive_regulation (induces) of Positive_regulation (activation) of TRPV1 in intestine
7) Confidence 0.50 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18194153 Disease Relevance 0 Pain Relevance 0.82
Activation of TRPV1 can induce persistent depolarization of the nerve terminals causing a decrease in their ability to generate and propagate action potentials.
Positive_regulation (induce) of Positive_regulation (Activation) of TRPV1 in nerve associated with action potential
8) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.52 Pain Relevance 0.58
This effect seems to be primarily mediated through activation of TRPV1 receptors that are known to be expressed by slowly conducting nociceptive primary afferent nerve fibers.


Positive_regulation (mediated) of Positive_regulation (activation) of TRPV1 in nerve
9) Confidence 0.50 Published 2005 Journal Cardiovasc. Res. Section Body Doc Link 15639479 Disease Relevance 0 Pain Relevance 0
By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in spinal lamina II neurons from post-natal mice.
Positive_regulation (activation) of Positive_regulation (capsaicin-induced) of TRPV1 in neurons associated with qutenza
10) Confidence 0.50 Published 2007 Journal Pain Section Abstract Doc Link 17317009 Disease Relevance 0 Pain Relevance 0.44
By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in spinal lamina II neurons from post-natal mice.
Positive_regulation (activation) of Positive_regulation (capsaicin-induced) of vanilloid receptor-1 in neurons associated with qutenza
11) Confidence 0.50 Published 2007 Journal Pain Section Abstract Doc Link 17317009 Disease Relevance 0 Pain Relevance 0.44
However, whether 12(S)-HpETE underlies TRPV1 channel activation during I/R is unknown.
Positive_regulation (underlies) of Positive_regulation (activation) of TRPV1
12) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17470568 Disease Relevance 0.46 Pain Relevance 0.33
After isoflurane anesthesia before euthanasia capsaicin caused a TRPV1-mediated increase in the magnitude of LA-LTP.
Positive_regulation (caused) of Positive_regulation (increase) of TRPV1 associated with anesthesia, qutenza, long-term potentiation, isoflurane and amygdala
13) Confidence 0.49 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.53
Outside the brain anandamide significantly decreases NOS activity via CB1 receptors, whereas TRPV1 stimulation by anandamide enhances NOS activity [45].
Positive_regulation (enhances) of Positive_regulation (stimulation) of TRPV1 in brain
14) Confidence 0.49 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.16
These data demonstrate that capsaicin initiates ROS generation through TRPV1 activation.
Positive_regulation (initiates) of Positive_regulation (activation) of TRPV1 associated with qutenza
15) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.06 Pain Relevance 0.46
TRPV1 activation induces increases in ROS production
Positive_regulation (induces) of Positive_regulation (activation) of TRPV1
16) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.36 Pain Relevance 0.32
The interactive relationship of these two types of receptors will be the target of further investigation since the present study suggests TRPV1 activation is inducing TNFR1 increases and/or activation.
Positive_regulation (inducing) of Positive_regulation (activation) of TRPV1
17) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.86 Pain Relevance 0.62
antibody, supporting the TRPV1 activation pathway through PKC?
Positive_regulation (supporting) of Positive_regulation (activation) of TRPV1
18) Confidence 0.49 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.57 Pain Relevance 0.61
We propose endogenous TNFalpha as a key player in cancer-related heat hyperalgesia and nociceptor sensitization that generates TRPV1 upregulation and sensitization via TNFR2.
Positive_regulation (generates) of Positive_regulation (upregulation) of TRPV1 in nociceptor associated with hyperalgesia, cancer and nociceptor
19) Confidence 0.49 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463260 Disease Relevance 1.63 Pain Relevance 0.96
Regardless of isolectin GS-IB4 (IB4)-staining, histamine potentiated [Ca(2+)](i) responses to acid (>or=pH 6.0) that were mediated by TRPV1 activation.
Positive_regulation (mediated) of Positive_regulation (activation) of TRPV1 in IB4
20) Confidence 0.49 Published 2010 Journal Neuroscience Section Abstract Doc Link 20006972 Disease Relevance 0.82 Pain Relevance 0.76

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