INT103386

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SLC9A1) intracellular (IL8) transmembrane transport (SLC9A1)
extracellular space (IL8) signal transduction (IL8) extracellular region (IL8)
Anatomy Link Frequency
epithelial cells 3
SLC9A1 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 100.00 Very High Very High Very High
Inflammation 3 94.20 High High
Inflammatory response 3 91.48 High High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 5 98.68 Very High Very High Very High
Disease 1 97.36 Very High Very High Very High
Mucositis 1 93.56 High High
INFLAMMATION 4 91.12 High High
Colitis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human gut epithelial cells, NHE inhibition using a variety of agents, including amiloride, 5-(N-methyl-N-isobutyl)amiloride, 5-(N-ethyl-N-isopropyl)- amiloride, harmaline, clonidine, and cimetidine, suppressed interleukin-8 (IL-8) production.
Negative_regulation (inhibition) of NHE in epithelial cells Negative_regulation (suppressed) of Gene_expression (production) of interleukin-8 in epithelial cells associated with clonidine
1) Confidence 0.02 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.97 Pain Relevance 0.36

General Comments

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