INT103535

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) chromosome (Obfc1)
intracellular (Gad1) nucleus (Obfc1) DNA binding (Obfc1)
Anatomy Link Frequency
globus pallidus 2
Obfc1 (Rattus norvegicus)
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
Substantia nigra 1 99.52 Very High Very High Very High
substance P 1 98.04 Very High Very High Very High
Enkephalin 3 96.60 Very High Very High Very High
Dopamine 5 94.80 High High
Neuropeptide 1 87.84 High High
Neurotransmitter 1 81.48 Quite High
Disease Link Frequency Relevance Heat
Disease 1 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lesion-induced increases in intraneuronal glutamate decarboxylase 67 kDa isoform (GAD67) mRNA levels on the lesion side were reversed by STN HFS in the substantia nigra, partially antagonized in the entopeduncular nucleus but unaffected in the globus pallidus.
STN Negative_regulation (reversed) of Positive_regulation (increases) of GAD67 in globus pallidus associated with glutamate and substantia nigra
1) Confidence 0.03 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077209 Disease Relevance 0.07 Pain Relevance 0.49

General Comments

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