INT103579

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.34
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
plasma 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 8 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
antagonist 34 99.98 Very High Very High Very High
Paracetamol 4 99.84 Very High Very High Very High
opioid receptor 58 99.74 Very High Very High Very High
narcan 8 98.40 Very High Very High Very High
Inflammation 8 97.52 Very High Very High Very High
Hyperalgesia 2 96.62 Very High Very High Very High
Antinociceptive 12 94.88 High High
Endogenous opioid 20 91.20 High High
Disease Link Frequency Relevance Heat
Dyspnea 6 99.54 Very High Very High Very High
INFLAMMATION 10 97.52 Very High Very High Very High
Hyperalgesia 2 96.62 Very High Very High Very High
Hypertension 3 90.40 High High
Nociception 10 55.96 Quite High
Inflammatory Pain 6 42.64 Quite Low
Pain 14 41.76 Quite Low
Overdose 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the hyperalgesia, as a consequence of peripheral inflammation induced by a variety of agents, is associated with increased dynorphin expression [18-20], and opioid receptor antagonists reversed the decrease in dynorphin level induced by paracetamol [21].
Negative_regulation (decrease) of Positive_regulation (induced) of dynorphin associated with paracetamol, hyperalgesia, dynorphin, inflammation, antagonist and opioid receptor
1) Confidence 0.42 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.32 Pain Relevance 1.75
On the other hand, the hyperalgesia, as a consequence of peripheral inflammation induced by a variety of agents, is associated with increased dynorphin expression [18-20], and opioid receptor antagonists reversed the decrease in dynorphin level induced by paracetamol [21].
Negative_regulation (reversed) of Positive_regulation (induced) of dynorphin associated with paracetamol, hyperalgesia, dynorphin, inflammation, antagonist and opioid receptor
2) Confidence 0.42 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.32 Pain Relevance 1.78
The decrease in BP after hyperventilation was associated with a decrease in plasma norepinephrine, Met-enkephalin and dynorphin B and an increase in beta-endorphin.
Negative_regulation (decrease) of Positive_regulation (increase) of dynorphin B in plasma associated with dynorphin, enkephalin and dyspnea
3) Confidence 0.02 Published 2002 Journal Peptides Section Abstract Doc Link 12084522 Disease Relevance 0.70 Pain Relevance 0.25

General Comments

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