INT103608

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 22 99.78 Very High Very High Very High
mu opioid receptor 8 93.52 High High
metalloproteinase 4 78.24 Quite High
opioid receptor 1 75.00 Quite High
Morphine 1 56.28 Quite High
Inflammation 1 50.00 Quite Low
aspirin 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Lung Cancer 2 81.16 Quite High
Repression 2 79.68 Quite High
INFLAMMATION 6 76.32 Quite High
Embryonal Carcinoma 1 62.48 Quite High
Injury 1 50.00 Quite Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to NSAIDs inhibits Sp1 binding to its promoter and abrogates CSE expression in HEK-293 cells transfected with a vector containing the core CSE promoter.
Negative_regulation (inhibits) of Sp1 Binding (binding) of
1) Confidence 0.35 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0 Pain Relevance 0
NSAID treatment reduces Sp1 DNA binding activity and phosphorylation and attenuates MMP-2 expression.
Negative_regulation (reduces) of Sp1 Binding (binding) of associated with cinod
2) Confidence 0.12 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.31 Pain Relevance 0.87
In vitro DNA CpG-methylation of the promoter partially blocked binding of the Sp1 factor but induced MeCP2 binding.
Negative_regulation (blocked) of Sp1 factor Binding (binding) of
3) Confidence 0.12 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20385708 Disease Relevance 0.06 Pain Relevance 0.36
NSAID treatment reduces Sp1 DNA binding activity and phosphorylation and attenuates MMP-2 expression.
Negative_regulation (reduces) of Sp1 Binding (activity) of associated with cinod
4) Confidence 0.09 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.31 Pain Relevance 0.87

General Comments

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