INT103638

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.88
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV) cytoskeleton (MEFV) nucleus (MEFV)
intracellular (MEFV) cytoplasm (MEFV)
Anatomy Link Frequency
skin 1
MEFV (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 1 93.60 High High
agonist 2 88.88 High High
Inflammation 43 88.40 High High
Ultiva 1 64.00 Quite High
anesthesia 25 61.52 Quite High
Fibrositis 97 50.60 Quite High
Pain 22 48.88 Quite Low
spastic colon 1 24.32 Low Low
chemokine 12 15.20 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 65 100.00 Very High Very High Very High
Celiac Disease 65 99.80 Very High Very High Very High
Hemosiderosis 2 99.54 Very High Very High Very High
Familial Mediterranean Fever 29 99.02 Very High Very High Very High
Disease Progression 1 96.16 Very High Very High Very High
Disease 104 94.94 High High
Syndrome 19 94.76 High High
Disorder Of Lipid Metabolism 16 94.40 High High
Dermatological Disease 1 91.60 High High
Bullous Skin Disease 1 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pyrin homotrimer, they propose, is autoinhibited by the association of its pyrin domain (PyD) with its own B-box.
Negative_regulation (autoinhibited) of pyrin
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0.04
The current hypothesis for the role of pyrin in FMF is that wild type pyrin inhibits, while mutated pyrin fails to inhibit, the inflammasome [39].
Negative_regulation (inhibit) of pyrin associated with familial mediterranean fever
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.89 Pain Relevance 0.17
MEF(10) decreased slightly (77.0% +/- 9.03%, P < 0.005) whereas MEF(FRC) did not (81.2% +/- 29.85%, not significant).
Negative_regulation (decreased) of MEF
3) Confidence 0.37 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12088943 Disease Relevance 0.14 Pain Relevance 0.21
We report an individual heterozygous for the M680I gene mutation with a clinical diagnosis of FMF using the Tel-Hashomer criteria.
Negative_regulation (diagnosis) of FMF associated with fever
4) Confidence 0.37 Published 2003 Journal BMC Nephrol Section Abstract Doc Link PMC194618 Disease Relevance 2.26 Pain Relevance 0.12
An important associated disease is dermatitis herpetiformis, a dermatological disease also known as "CD of the skin," with a high frequency of CD in adults but with a much lower frequency in childhood CD as in our study.36,37 Another associated disease in our study was idiopathic pulmonary hemosiderosis, a rare condition of unknown autoimmune etiology mainly affecting children and adolescents in which a GFD may be very effective for the regression of the pulmonary hemosiderosis.38 Morever, 1 patient had both FMF and CD, and this is the first description of association of CD and FMF.39
Negative_regulation (had) of FMF in skin associated with celiac disease, dermatological disease, hemosiderosis, bullous skin disease and disease
5) Confidence 0.15 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.92 Pain Relevance 0
In 1830, Southwood Smith published A Treatise on Fever, which was, perhaps, his most important medical text.
Negative_regulation (published) of Treatise on Fever associated with fever
6) Confidence 0.12 Published 2008 Journal Bulletin of the History of Medicine Section Body Doc Link PMC2646604 Disease Relevance 0.60 Pain Relevance 0
When the patients later received fospropofol the EEG showed a more rapid decrease in MEF, dropping quickly to 1 Hz and remaining less than 3 Hz throughout the duration of the infusion. ?
Negative_regulation (decrease) of MEF
7) Confidence 0.10 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2801588 Disease Relevance 0 Pain Relevance 0

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