INT103672

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.45
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1)
Anatomy Link Frequency
epithelium 1
PBMC 1
Serpinf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
Opioid 1 98.36 Very High Very High Very High
Antinociceptive 1 95.36 Very High Very High Very High
Angina 1 50.00 Quite Low
chemokine 3 30.96 Quite Low
Pain 3 25.00 Low Low
aspirin 1 25.00 Low Low
cytokine 6 10.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 39 100.00 Very High Very High Very High
Hypoxia 2 98.20 Very High Very High Very High
Age-related Macular Degeneration 9 86.92 High High
Pressure And Volume Under Development 2 83.88 Quite High
Glaucoma 38 83.00 Quite High
Cancer 7 80.24 Quite High
Necrosis 2 79.76 Quite High
Myopia 1 69.60 Quite High
Death 10 67.88 Quite High
Ganglion Cysts 9 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cellular localization of PEDF and glial fibrillary acidic protein (GFAP) was determined by immunohistochemistry.
Localization (localization) of PEDF
1) Confidence 0.69 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.79 Pain Relevance 0.08
REHDER possesses analgesic and anti-inflammatory activities, which may be mediated, at least partly, through the suppression of inflammatory mediators or their release</spa</span>n> suggested by the animal experiment.
Localization (release) of SDF associated with inflammatory mediators, inflammation and analgesic
2) Confidence 0.65 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17329839 Disease Relevance 0.60 Pain Relevance 0.60
PEDF, a 50-kDa protein secreted by the retinal pigment epithelium, inhibits the growth of new blood vessels, most likely via the PI3K/Akt pathway, and shows an inverse pattern of expression to VEGF and EPO [47].
Localization (secreted) of PEDF in epithelium
3) Confidence 0.63 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.95 Pain Relevance 0.06
Finally, although SDF-1alpha suppressed the spontaneous release of these inflammatory mediators in unstable angina, enhancing effects were seen in unstimulated PBMC from healthy control subjects, possibly reflecting that PBMC in unstable angina are preactivated in vivo.
Localization (release) of SDF in PBMC
4) Confidence 0.01 Published 2002 Journal Circulation Section Body Doc Link 12093767 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.

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