INT103806

Context Info Confidence 0.41 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.72 Pain Relevance 0.31

Anatomy Link Frequency superior 1 uterine 1 Aaiq4 (Mus musculus)

Pain Link Frequency Relevance Heat endometriosis 5 93.32 pain pelvic 1 88.24 agonist 8 64.96 Peripheral nervous system 1 55.20 Pain 4 5.00 imagery 3 5.00 palliative 2 5.00 ketamine 2 5.00 chemokine 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 7 99.60 Cancer 141 99.56 Breast Cancer 58 99.24 Weight Gain 4 97.92 Obesity 133 96.84 Metastasis 108 95.12 Apoptosis 6 90.88 Reprotox - General 3 2 88.24 Death 6 87.72 Recurrence 9 87.48

Sentences Mentioned In

Key:

Protein

Mutation

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Anatomy

Negation

Speculation

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Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.

Negative_regulation (disruption) of aromatase in uterine

1) Confidence 0.41 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12107266 Disease Relevance 0.57 Pain Relevance 0.25

Aromatase deficiency, during which E2 is not produced, results in the development of adiposity and obesity [66].

Negative_regulation (deficiency) of Aromatase associated with obesity

2) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.37 Pain Relevance 0.03

Unlike most current cancer therapies, including aromatase inhibitors, which cause bone loss [67], 2ME2 and SD-208 have bone-sparing effects that may contribute the beneficial effect on bone metastases [60], [68].

Negative_regulation (inhibitors) of aromatase associated with cancer and metastasis

3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.06 Pain Relevance 0

Available clinical evidence, although limited, suggests that the response to aromatase inhibitors in HER-2 positive breast cancers is superior to tamoxifen.

Negative_regulation (inhibitors) of aromatase in superior associated with breast cancer

4) Confidence 0.01 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2383915 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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