INT103824

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 17.42
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
MCF7 2
MIA PaCa-2 2
astrocytes 2
A549 2
SH-SY5Y 1
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 29 99.98 Very High Very High Very High
cytokine 38 99.84 Very High Very High Very High
diclofenac 480 99.22 Very High Very High Very High
Codeine 18 99.04 Very High Very High Very High
qutenza 9 96.12 Very High Very High Very High
metalloproteinase 16 94.76 High High
Inflammation 96 94.48 High High
lidocaine 1 93.60 High High
Opioid 9 91.20 High High
alcohol 30 89.28 High High
Disease Link Frequency Relevance Heat
Stress 130 100.00 Very High Very High Very High
Endometriosis (extended) 9 100.00 Very High Very High Very High
Infection 6 99.82 Very High Very High Very High
Cancer 170 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 99.58 Very High Very High Very High
Apoptosis 358 99.36 Very High Very High Very High
Breast Cancer 244 99.16 Very High Very High Very High
Ureteral Obstruction 25 98.84 Very High Very High Very High
Cytomegalovirus Infection 66 98.66 Very High Very High Very High
Lung Injury 5 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, morphine increased the activity of mitochondrial Mn-containing superoxide dismutase (MnSOD) in HL-60 cells, but decreased the MnSOD activity in A549 and MCF7 cells.
Positive_regulation (increased) of mitochondrial Mn-containing superoxide dismutase in MCF7 associated with morphine
1) Confidence 0.70 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894522 Disease Relevance 0.98 Pain Relevance 0.82
In addition, morphine increased the activity of mitochondrial Mn-containing superoxide dismutase (MnSOD) in HL-60 cells, but decreased the MnSOD activity in A549 and MCF7 cells.
Positive_regulation (increased) of MnSOD in MCF7 associated with morphine
2) Confidence 0.70 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894522 Disease Relevance 0.98 Pain Relevance 0.82
On the other hand, in rat astrocytes the lipopolysaccharide induced an increase of SOD2 mRNA, but not of the SOD2 protein [49].
Positive_regulation (increase) of SOD2 mRNA in astrocytes
3) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.19 Pain Relevance 0.14
In this paper, the addition of a heterologous thioredoxin to diclofenac-treated cultures of SH-SY5Y led to an enhancement of the SOD2 levels, as well as to a reduction of the apoptosis.
Positive_regulation (enhancement) of SOD2 in SH-SY5Y associated with apoptosis and diclofenac
4) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.37 Pain Relevance 0.08
It is known that the induction of SOD2 can be mediated by various macromolecules, such as interleukyn-1 [50], lipopolysaccarides [51], and tumor necrosis factor-?
Positive_regulation (induction) of SOD2 associated with necrosis and cancer
5) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.31 Pain Relevance 0.13
Egan and colleagues [16] reported a slightly elevated OR for the MnSOD genotype in women who used oral contraceptives, but only a weak association among users of hormone replacement therapy.
Positive_regulation (elevated) of MnSOD
6) Confidence 0.50 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.45 Pain Relevance 0.04
The addition of increasing concentrations of SsTrx allowed a restoration of the SOD2 level, thus counteracting the effect of diclofenac.
Positive_regulation (restoration) of SOD2 associated with diclofenac
7) Confidence 0.49 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.27 Pain Relevance 0.27
This protection was accompanied by increased pulmonary MnSOD, VEGF expression and decreased apoptosis.
Positive_regulation (increased) of MnSOD associated with apoptosis
8) Confidence 0.49 Published 2002 Journal Front. Biosci. Section Abstract Doc Link 12108429 Disease Relevance 0.68 Pain Relevance 0.17
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Positive_regulation (increased) of MnSOD in MIA PaCa-2
9) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.48 Pain Relevance 0
Mitochondrial manganese-containing superoxide dismutase (MnSOD) activity and mRNA expression were assayed by activity staining after separation on the polyacrylamide gel electrophoresis, and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Positive_regulation (assayed) of MnSOD
10) Confidence 0.47 Published 2003 Journal Anesthesiology Section Body Doc Link 12606908 Disease Relevance 0.07 Pain Relevance 0
Several investigators hypothesize that MnSOD may act as a tumor suppressor gene in breast epithelial cells [6,7,9].
Spec (may) Positive_regulation (act) of MnSOD in epithelial cells associated with cancer
11) Confidence 0.47 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.37 Pain Relevance 0.05
On the other hand, in rat astrocytes the lipopolysaccharide induced an increase of SOD2 mRNA, but not of the SOD2 protein [49].
Positive_regulation (increase) of SOD2 protein in astrocytes
12) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.20 Pain Relevance 0.14
When cells were incubated with an archaeal exogenous thioredoxin, an attenuation of the diclofenac-induced apoptosis was observed, together with an increase of SOD2 protein levels.
Positive_regulation (increase) of SOD2 protein associated with apoptosis and diclofenac
13) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2896885 Disease Relevance 0.70 Pain Relevance 0.29
The ORs for MnSOD stratified on menopausal status are presented in Table 2.
Positive_regulation (presented) of MnSOD associated with endometriosis (extended)
14) Confidence 0.44 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.54 Pain Relevance 0.03
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Positive_regulation (increased) of MnSOD in MIA PaCa-2
15) Confidence 0.42 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.48 Pain Relevance 0
Moreover, proteomic analysis revealed the induction of mitochondrial superoxide dismutase in response to morphine treatment.
Positive_regulation (induction) of mitochondrial superoxide dismutase associated with morphine
16) Confidence 0.35 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.90 Pain Relevance 0.80
HIV-1 infection did not induce mitochondrial superoxide dismutase.
Neg (not) Positive_regulation (induce) of mitochondrial superoxide dismutase associated with acquired immune deficiency syndrome or hiv infection and infection
17) Confidence 0.35 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.90 Pain Relevance 0.79
The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.
Positive_regulation (upregulation) of SOD2 associated with qutenza and apoptosis
18) Confidence 0.35 Published 2008 Journal Proteomics Section Abstract Doc Link 18991268 Disease Relevance 0.79 Pain Relevance 0.64
In addition, morphine increased the activity of mitochondrial Mn-containing superoxide dismutase (MnSOD) in HL-60 cells, but decreased the MnSOD activity in A549 and MCF7 cells.
Positive_regulation (increased) of mitochondrial Mn-containing superoxide dismutase in A549 associated with morphine
19) Confidence 0.24 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894522 Disease Relevance 0.98 Pain Relevance 0.82
In addition, morphine increased the activity of mitochondrial Mn-containing superoxide dismutase (MnSOD) in HL-60 cells, but decreased the MnSOD activity in A549 and MCF7 cells.
Positive_regulation (increased) of MnSOD in A549 associated with morphine
20) Confidence 0.24 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894522 Disease Relevance 0.98 Pain Relevance 0.82

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