INT103909

Context Info Confidence 0.77 First Reported 2002 Last Reported 2010 Negated 0 Speculated 3 Reported most in Body Documents 37 Total Number 40 Disease Relevance 21.90 Pain Relevance 7.36

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2) cytoplasm (NOD2)

Anatomy Link Frequency Paneth cells 3 HL-60 2 epithelial cells 2 dental pulp 2 macrophages 1 NOD2 (Homo sapiens) NOD2 - P268S (1)

Pain Link Frequency Relevance Heat Inflammation 409 100.00 COX2 3 100.00 Crohn's disease 333 99.96 spinal inflammation 11 98.24 Inflammatory stimuli 13 97.56 rheumatoid arthritis 14 97.36 Inflammatory mediators 21 97.24 cINOD 10 96.44 pulpitis 6 93.44 cytokine 135 88.24

Disease Link Frequency Relevance Heat INFLAMMATION 400 100.00 Disease 750 99.96 Mycobacterial Infection 5 99.74 Inflammatory Bowel Disease 382 99.50 Glioma 2 98.88 Disease Susceptibility 33 98.48 Low Back Pain 6 98.24 Rheumatoid Arthritis 14 97.36 Contagious Ecthyma 24 97.08 Repression 48 96.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

High constitutive expression of NOD2 has been shown in Paneth cells [37], which represent specialized IECs secreting antimicrobial peptides in the terminal ileum.

Gene_expression (expression) of NOD2 in ileum

1) Confidence 0.77 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.59 Pain Relevance 0.29

We found clear expressions of TLR2, NOD1, and NOD2 and a faint expression of TLR4 in human dental pulp fibroblasts (HDPF) by RT-PCR and flow cytometry.

Spec (clear) Gene_expression (expressions) of NOD2 in dental pulp

2) Confidence 0.73 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.45

We found that Nod1, Nod2, and NLRX1 were expressed at comparable levels in both cell types with an apparently uniform expression level in the primary corneal cell samples.

Gene_expression (expressed) of Nod2

3) Confidence 0.73 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.03

Surprisingly, after 24 h, although Nod1 and Nod2 expression increased compared to the 6 h samples, all the studied Nod expression remained low compared to the non-exposed samples (Figure 6B).

Gene_expression (expression) of Nod2

4) Confidence 0.73 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.10

In addition to its expression on cells of the monocyte lineage, the NOD2 protein is also expressed on gut epithelial cells.

Gene_expression (expressed) of NOD2 in epithelial cells

5) Confidence 0.73 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564298 Disease Relevance 1.07 Pain Relevance 0.06

Within the exon 1b of the alternative 5'-UTR region of human NOD2, three uORFs with variable lengths were identified upstream of the main ORF located in exon 2.

Gene_expression (region) of NOD2 associated with contagious ecthyma

6) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.15 Pain Relevance 0

We thus hypothesize that alternative splicing of the two novel isoforms contributes to the upregulation of NOD2 protein levels observed under inflammatory conditions and the high constitutive expression in distinct cell types, i.e. monocytic cells and, possibly, Paneth cells.

Gene_expression (expression) of NOD2 in Paneth cells associated with inflammation

7) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.33 Pain Relevance 0.17

A genetic ablation of Nod2 in mice leads to a distinct defect in cryptdin (?

Gene_expression (ablation) of Nod2

8) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.58 Pain Relevance 0.28

Of the children with NOD2/CARD15 variants...[32]

Gene_expression (variants) of NOD2

9) Confidence 0.65 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

Of the children with NOD2/CARD15 variants...[32]

Gene_expression (variants) of CARD15

10) Confidence 0.65 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

As in Crohn's disease, CARD15/NOD2 mutation is believed to be responsible for the granulomatous autoinflammatory reactions probably triggered by microorganisms in BS.

Gene_expression (mutation) of CARD15 associated with crohn's disease, syndrome and disease

11) Confidence 0.65 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18718560 Disease Relevance 1.06 Pain Relevance 0.31

A strong linkage disequilibrium was found between the NOD2/CARD15 Pro268Ser loci and three other studied loci of NOD2/CARD15.

Gene_expression (loci) of CARD15 (P268S)

12) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 0.56 Pain Relevance 0.24

A strong linkage disequilibrium was found between the NOD2/CARD15 Pro268Ser loci and three other studied loci of NOD2/CARD15.

Gene_expression (loci) of CARD15

13) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 0.61 Pain Relevance 0.29

As in Crohn's disease, CARD15/NOD2 mutation is believed to be responsible for the granulomatous autoinflammatory reactions probably triggered by microorganisms in BS.

Gene_expression (mutation) of NOD2 associated with crohn's disease, syndrome and disease

14) Confidence 0.65 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18718560 Disease Relevance 1.06 Pain Relevance 0.31

OBJECTIVE: To investigate the role of the gene NOD2 in susceptibility to, and clinical manifestations of, ankylosing spondylitis (AS).

Spec (investigate) Gene_expression (role) of NOD2 associated with spinal inflammation

15) Confidence 0.64 Published 2002 Journal Arthritis Rheum. Section Abstract Doc Link 12115195 Disease Relevance 0.17 Pain Relevance 0.10

To determine to what extent the lipopolysaccharide-induced TNF-alpha production capacity in vivo and ex vivo is determined by polymorphisms in toll-like receptor-4 (TLR4), the TNF-alpha promoter region and Nod2, we screened for two TLR4 polymorphisms, a Nod2 polymorphism and the TNF-alpha promoter polymorphisms.

Gene_expression (polymorphism) of Nod2

16) Confidence 0.64 Published 2004 Journal Cytokine Section Abstract Doc Link 15016407 Disease Relevance 0.49 Pain Relevance 0.15

Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.

Gene_expression (Roles) of NOD2 in fibroblasts associated with cox2

17) Confidence 0.63 Published 2009 Journal J. Dent. Res. Section Title Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.55

B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?

Gene_expression (/) of Nod2

18) Confidence 0.63 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.27

The time-dependent appearance of pIkB after PGN-ECndss treatment implies the presence of functional Nod1 and/or Nod2 proteins in HCE-T cells that are able to recognize the peptidoglycan ligand and trigger the NF?

Gene_expression (presence) of Nod2 in T cells

19) Confidence 0.63 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.04

A strong linkage disequilibrium was found between the NOD2/CARD15 Pro268Ser loci and three other studied loci of NOD2/CARD15.

Gene_expression (loci) of NOD2

20) Confidence 0.61 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 0.56 Pain Relevance 0.24

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