INT103928

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
T cell 3
Cd28 (Mus musculus)
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 12 98.64 Very High Very High Very High
Inflammation 8 54.96 Quite High
cytokine 12 30.80 Quite Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 75.00 Quite High
Death 2 61.04 Quite High
Sepsis 2 60.16 Quite High
Apoptosis 4 56.64 Quite High
Autoimmune Disease 9 5.00 Very Low Very Low Very Low
Multiple Sclerosis 7 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Lyme Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine whether impairment of IL-17 production with anti-CD28 mAb was dependent on the TCR-signalling intensity, CD4+ T cells were stimulated with titrated doses of anti-CD3 and a fixed amount of anti-CD28 mAb.
CD28 mAb Neg (impairment) Spec (whether) Binding (impairment) of TCR in T cells
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.17 Pain Relevance 0
In this study we show that CPS and nordihydrocapsiate (CPT) inhibit early and late events in T cell activation, including CD69, CD25 and ICAM-1 cell surface expression, progression to the S phase of the cell cycle and proliferation in response to TCR and CD28 co-engagement.
CD28 Binding (co-engagement) of TCR in T cell associated with qutenza
2) Confidence 0.02 Published 2002 Journal Eur. J. Immunol. Section Abstract Doc Link 12115659 Disease Relevance 0.19 Pain Relevance 0.49
In this study we show that CPS and nordihydrocapsiate (CPT) inhibit early and late events in T cell activation, including CD69, CD25 and ICAM-1 cell surface expression, progression to the S phase of the cell cycle and proliferation in response to TCR and CD28 co-engagement.
CD28 Binding (co-engagement) of TCR in T cell associated with qutenza
3) Confidence 0.02 Published 2002 Journal Eur. J. Immunol. Section Abstract Doc Link 12115659 Disease Relevance 0.19 Pain Relevance 0.49

General Comments

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