INT10414

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Context Info
Confidence 0.62
First Reported 1984
Last Reported 1992
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.43
Pain Relevance 2.16

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Anatomy Mention Frequency
brain 2
pituitary 2
gth (Salmonella enterica)
Pain Term Frequency Confidence Heat
agonist 16 99.58 Very High Very High Very High
Clonidine 5 99.14 Very High Very High Very High
antagonist 17 98.56 Very High Very High Very High
Serotonin 5 98.10 Very High Very High Very High
fluoxetine 2 90.56 High High
Disease Term Frequency Confidence Heat
Recurrence 5 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketanserin (10 micrograms/g; ip), a 5-HT antagonist, did not modify basal GtH levels; however, ketanserin blocked the 5-HT induced release of GtH.
Positive_regulation (induced) of Localization (release) of GtH associated with antagonist
1) Confidence 0.62 Published 1988 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3266487 Disease Relevance 0 Pain Relevance 0.21
Serotonin (20 micrograms/ml media) alone, and in combination with LHRHa (10 ng/ml media), significantly stimulated GtH release from the pituitaries of gonadally mature 2- and 3-year-old female croaker during an 18-hr incubation in vitro, but not from pituitaries of gonadally regressed fish.
Positive_regulation (stimulated) of Neg (not) Localization (release) of GtH associated with serotonin
2) Confidence 0.43 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1490584 Disease Relevance 0 Pain Relevance 0.22
Additions of the alpha-agonist phenylephrine, and the alpha 1-agonist 6-fluoronorepinephrine, but not the alpha 2-agonist clonidine, nor the beta-agonist isoproterenol, also enhanced GTH secretion.
Positive_regulation (enhanced) of Localization (secretion) of GTH associated with agonist and clonidine
3) Confidence 0.40 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1682833 Disease Relevance 0 Pain Relevance 0.54
Static incubations of dispersed goldfish pituitary cells with 1-100 nM norepinephrine (NE) stimulated gonadotropin (GTH) release.
Positive_regulation (stimulated) of Localization (release) of GTH in pituitary
4) Confidence 0.40 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1682833 Disease Relevance 0 Pain Relevance 0.49
These results suggest that NE stimulates GtH release by alpha-adrenergic mechanisms at the brain and/or pituitary level in female goldfish in a sexually regressed or early ovarian recrudescence condition.
Positive_regulation (stimulates) of Localization (release) of GtH in brain associated with recurrence
5) Confidence 0.39 Published 1984 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 6745634 Disease Relevance 0.43 Pain Relevance 0.20
These results suggests that NE directly stimulates GTH secretion independent of sGnRH receptors via alpha 1-like adrenergic receptors.
Neg (independent) Positive_regulation (independent) of Localization (secretion) of GTH
6) Confidence 0.29 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1682833 Disease Relevance 0 Pain Relevance 0.49

General Comments

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