INT104162

Context Info Confidence 0.31 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.28 Pain Relevance 0.58

aging (CALCA) intracellular (CALCA) cell-cell signaling (CALCA) cytoplasm (CALCA) signal transducer activity (HTR1D) extracellular space (CALCA)

Anatomy Link Frequency cranial 2 HTR1D (Homo sapiens) CALCA (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 6 99.80 agonist 1 96.44 Migraine 1 95.28 headache 1 94.52 medulla 2 82.80

Disease Link Frequency Relevance Heat Headache 2 95.28 Syndrome 1 94.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suggests that 5-HT1D-receptors can regulate the release of CGRP and substance P and may be relevant to the clinical effectiveness of 5-HT1B/1D-receptor agonists in the treatment of migraine and other cranial pain syndromes.

5-HT1D Regulation (regulate) of Localization (release) of CGRP in cranial associated with syndrome, migraine, agonist, headache and substance p

1) Confidence 0.31 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12133041 Disease Relevance 0.28 Pain Relevance 0.58

General Comments

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